OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 3 — Oct. 1, 2010
  • pp: 943–954

Diffuse optical signals in response to peripheral nerve stimulation reflect skeletal muscle kinematics

M. Kelley Erb, Debbie K. Chen, Angelo Sassaroli, Sergio Fantini, and Peter R. Bergethon  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 3, pp. 943-954 (2010)
http://dx.doi.org/10.1364/BOE.1.000943


View Full Text Article

Enhanced HTML    Acrobat PDF (10828 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Previously we have reported a near-infrared optical response in the region occupied by a peripheral nerve that is distal to the site of electrical stimulation of that peripheral nerve. This “intermediate” signal is vascular in nature but its biological origin not been elucidated. In the present study, an animal model of the signal has been created and our human studies expanded to directly investigate the contribution of non-artifactual vascular motion induced by muscle contraction to the biological origin of this signal. Under non-invasive conditions during stimulation of the exposed sciatic nerve of the Sprague-Dawley rat, optical responses are robust. These signals can be abolished both pharmacologically and surgically using methods that eliminate muscle motion while leaving the electrophysiological health of the nerve intact. In human studies, signals that are elicited on stimulation of nerves containing motor axons, both within and outside the predicted imaging volume of the spectrometer, have similar temporal characteristics of those previously observed. Moreover, stimulation of sensory nerves alone does not elicit an optical response. These results strongly suggest that the intermediate signals are derived from stimulus-induced muscle contraction (whether via an innervating nerve or by direct stimulation) causing translational vascular motion within the optically interrogated region.

© 2010 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: June 8, 2010
Revised Manuscript: August 24, 2010
Manuscript Accepted: September 14, 2010
Published: September 16, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

Citation
M. Kelley Erb, Debbie K. Chen, Angelo Sassaroli, Sergio Fantini, and Peter R. Bergethon, "Diffuse optical signals in response to peripheral nerve stimulation reflect skeletal muscle kinematics," Biomed. Opt. Express 1, 943-954 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-3-943


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. Y. Tong, J. M. Martin, A. Sassaroli, P. R. Clervil, P. R. Bergethon, and S. Fantini, “Fast optical signals in the peripheral nervous system,” J. Biomed. Opt. 11(4), 044014 (2006). [CrossRef] [PubMed]
  2. D. K. Chen, Y. Tong, A. Sassaroli, P. R. Bergethon, and S. Fantini, “Fast optical response to electrical activation in peripheral nerves - art. no. 643104,” Multimodal Biomedical Imaging II 6431, 43104–43104 43100 (2007).
  3. S. Fantini, D. K. Chen, J. M. Martin, A. Sassaroli, and P. R. Bergethon, “Near-infrared signals associated with electrical stimulation of peripheral nerves,” Proc SPIE 7174 (2009).
  4. J. Steinbrink, F. C. Kempf, A. Villringer, and H. Obrig, “The fast optical signal--robust or elusive when non-invasively measured in the human adult?” Neuroimage 26(4), 996–1008 (2005). [CrossRef] [PubMed]
  5. D. K. Chen, M. K. Erb, Y. Yu, A. Sassaroli, P. R. Bergethon, and S. Fantini, “Spectral and Spatial Features of Diffuse Optical Signals in Response to Peripheral Nerve Stimulation,” submitted.
  6. S. Virmani, D. K. Tempe, V. Datt, A. S. Tomar, A. Banerjee, H. S. Minhas, and S. Goel, “Effect of muscle relaxants on heart rate, arterial pressure, intubation conditions and onset of neuromuscular block in patients undergoing valve surgery,” Ann. Card. Anaesth. 9(1), 37–43 (2006). [PubMed]
  7. A. Esmaoglu, A. Akin, A. Mizrak, Y. Turk, and A. Boyaci, “Addition of cisatracurium to lidocaine for intravenous regional anesthesia,” J. Clin. Anesth. 18(3), 194–197 (2006). [CrossRef] [PubMed]
  8. S. Fantini, M. A. Franceschini, J. B. Fishkin, B. Barbieri, and E. Gratton, “Quantitative-Determination of the Absorption-Spectra of Chromophores in Strongly Scattering Media - a Light-Emitting-Diode Based Technique,” Appl. Opt. 33(22), 5204–5213 (1994). [CrossRef]
  9. S. Fantini, M. A. Franceschini, and E. Gratton, “Semi-Infinite-Geometry Boundary-Problem for Light Migration in Highly Scattering Media - a Frequency-Domain Study in the Diffusion-Approximation,” J. Opt. Soc. Am. B 11(10), 2128–2138 (1994). [CrossRef]
  10. V. Quaresima, M. A. Franceschini, S. Fantini, E. Gratton, and M. Ferrari, “Difference in leg muscles oxygenation during treadmill exercise by a new near infrared frequency-domain oximeter,” Photon Propagation in Tissues Iii, Proceedings Of 3194, 116–120532 (1998).
  11. H. L. Liu, D. A. Boas, Y. T. Zhang, A. G. Yodh, and B. Chance, “A simplified approach to characterize optical properties and blood oxygenation in tissue using continuous near infrared,” Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, Proceedings of, Pts 1 and 2 2359, 496–502880 (1995).
  12. C. Chen, N. Yamaguchi, and F. Varin, “Dose-dependency of pharmacokinetic/pharmacodynamic parameters after intravenous bolus doses of cisatracurium,” Br. J. Anaesth. 101(6), 788–797 (2008). [CrossRef] [PubMed]
  13. F. Buchthal and H. Schmalbruch, “Contraction times and fibre types in intact human muscle,” Acta Physiol. Scand. 79(4), 435–452 (1970). [CrossRef] [PubMed]
  14. R. Close, “Dynamic Properties of Fast and Slow Skeletal Muscles of the Rat during Development,” J. Physiol. 173, 74–95 (1964). [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited