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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 3 — Oct. 1, 2010
  • pp: 967–974

Terahertz pulsed imaging of knee cartilage

Wai-Chi Kan, Win-Sze Lee, Wing-Hoi Cheung, Vincent P. Wallace, and Emma Pickwell-MacPherson  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 3, pp. 967-974 (2010)
http://dx.doi.org/10.1364/BOE.1.000967


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Abstract

Osteoarthritis (OA) is a common form of arthritis caused by cartilage degeneration. In this paper, we investigate the potential use of terahertz (THz) pulsed imaging to quantitatively measure the early symptoms of OA in an animal model. THz images of excised rabbit femoral condyles were taken. We observe THz waves reflected off different layers within samples and demonstrate that the optical delay between reflections can give a quantitative measure of the thicknesses of particular tissues within cartilage.

© 2010 OSA

OCIS Codes
(000.1430) General : Biology and medicine
(120.4825) Instrumentation, measurement, and metrology : Optical time domain reflectometry
(110.6795) Imaging systems : Terahertz imaging

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: July 26, 2010
Revised Manuscript: September 16, 2010
Manuscript Accepted: September 17, 2010
Published: September 20, 2010

Citation
Wai-Chi Kan, Win-Sze Lee, Wing-Hoi Cheung, Vincent P. Wallace, and Emma Pickwell-MacPherson, "Terahertz pulsed imaging of knee cartilage," Biomed. Opt. Express 1, 967-974 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-3-967


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