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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 4 — Nov. 1, 2010
  • pp: 1047–1059

Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans

Amardeep S. G. Singh, Christoph Kolbitsch, Tilman Schmoll, and Rainer A. Leitgeb  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 4, pp. 1047-1059 (2010)
http://dx.doi.org/10.1364/BOE.1.001047


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Abstract

Doppler optical coherence tomography has the capability to measure blood flow quantitatively and in vivo. As only the axial component of the velocity can be assessed, the measurements have to be corrected for the angle of the vessels. We present a novel approach to extract quantitative flow data from circumpapillary scans in vivo on the human retina by registering the circular scan to a reference volume scan and extracting the angle directly from the volume. In addition, we perform phase unwrapping and interpolation of the flow under the assumption of a parabolic flow profile. We demonstrate the repeatability of the methods by applying it to different retinal vessels, achieving coefficients of variation of the average velocity of 3 to 8%. Results on the pulsatility and resistance index are also presented.

© 2010 OSA

OCIS Codes
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: July 30, 2010
Revised Manuscript: September 20, 2010
Manuscript Accepted: September 29, 2010
Published: October 1, 2010

Citation
Amardeep S. G. Singh, Christoph Kolbitsch, Tilman Schmoll, and Rainer A. Leitgeb, "Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans," Biomed. Opt. Express 1, 1047-1059 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-4-1047


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