Detection of nanoscale structural changes in bone using random lasers

doi:10.1364/BOE.1.001401

Detection of nanoscale structural changes in bone using random lasers

Qinghai Song, Zhengbin Xu, Seung Ho Choi, Xuanhao Sun, Shumin Xiao, Ozan Akkus, and Young L. Kim »View Author Affiliations

Biomedical Optics Express, Vol. 1, Issue 5, pp. 1401-1407 (2010)
http://dx.doi.org/10.1364/BOE.1.001401

View Full Text Article

Enhanced HTML Acrobat PDF (958 KB)

Journal Search
Article Lookup

Article Tools

Citations

Alert me when this article is cited
Export Citation/Save

Abstract
Article Info
References (20)
Cited By
Figures (6)
Metrics
Related Content

Abstract

We demonstrate that the unique characteristics of random lasing in bone can be used to assess nanoscale structural alterations as a mechanical or structural biosensor, given that bone is a partially disordered biological nanostructure. In this proof-of-concept study, we conduct photoluminescence experiments on cortical bone specimens that are loaded in tension under mechanical testing. The ultra-high sensitivity, the large detection area, and the simple detection scheme of random lasers allow us to detect prefailure damage in bone at very small strains before any microscale damage occurs. Random laser-based biosensors could potentially open a new possibility for highly sensitive detection of nanoscale structural and mechanical alterations prior to overt microscale changes in hard tissue and biomaterials.

OCIS Codes
(140.2050) Lasers and laser optics : Dye lasers
(140.4780) Lasers and laser optics : Optical resonators
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Biosensors and Molecular Diagnostics

History
Original Manuscript: October 5, 2010
Revised Manuscript: November 9, 2010
Manuscript Accepted: November 9, 2010
Published: November 11, 2010

Citation
Qinghai Song, Zhengbin Xu, Seung Ho Choi, Xuanhao Sun, Shumin Xiao, Ozan Akkus, and Young L. Kim, "Detection of nanoscale structural changes in bone using random lasers," Biomed. Opt. Express 1, 1401-1407 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-5-1401

Sort: Author | Year | Journal | Reset

References

H. Cao, “Review on latest developments in random lasers with coherent feedback,” J.Phys. A Math. Gen. 38(49), 10497–10535 (2005). [CrossRef]
D. S. Wiersma, “The physics and applications of random lasers,” Nat. Phys. 4(5), 359–367 (2008). [CrossRef]
P. Pradhan and N. Kumar, “Localization of light in coherently amplifying random media,” Phys. Rev. B Condens. Matter 50(13), 9644–9647 (1994). [CrossRef] [PubMed]
H. Cao, Y. G. Zhao, S. T. Ho, E. W. Seelig, Q. H. Wang, and R. P. H. Chang, “Random laser action in semiconductor powder,” Phys. Rev. Lett. 82(11), 2278–2281 (1999). [CrossRef]
R. C. Polson, A. Chipouline, and Z. V. Vardeny, “Random lasing in pi-conjugated films and infiltrated opals,” Adv. Mater. 13(10), 760–764 (2001). [CrossRef]
R. C. Polson and Z. V. Vardeny, “Random lasing in human tissues,” Appl. Phys. Lett. 85(7), 1289–1291 (2004). [CrossRef]
A. Tulek, R. C. Polson, and Z. V. Vardeny, “Naturally occurring resonators in random lasing of pi-conjugated polymer films,” Nat. Phys. 6(4), 303–310 (2010). [CrossRef]
X. Wu, W. Fang, A. Yamilov, A. A. Chabanov, A. A. Asatryan, L. C. Botten, and H. Cao, “Random lasing in weakly scattering systems,” Phys. Rev. A 74(5), 053812 (2006). [CrossRef]
C. Vanneste, P. Sebbah, and H. Cao, “Lasing with resonant feedback in weakly scattering random systems,” Phys. Rev. Lett. 98(14), 143902 (2007). [CrossRef] [PubMed]
S. Mujumdar, M. Ricci, R. Torre, and D. S. Wiersma, “Amplified extended modes in random lasers,” Phys. Rev. Lett. 93(5), 053903 (2004). [CrossRef] [PubMed]
S. Mujumdar, V. Turck, R. Torre, and D. S. Wiersma, “Chaotic behavior of a random laser with static disorder,” Phys. Rev. A 76(3), 033807 (2007). [CrossRef]
R. C. Polson and Z. V. Vardeny, “Organic random lasers in the weak-scattering regime,” Phys. Rev. B 71(4), 045205 (2005). [CrossRef]
Q. Song, S. Xiao, Z. Xu, J. Liu, X. Sun, V. Drachev, V. M. Shalaev, O. Akkus, and Y. L. Kim, “Random lasing in bone tissue,” Opt. Lett. 35(9), 1425–1427 (2010). [CrossRef] [PubMed]
R. O. Ritchie, M. J. Buehler, and P. Hansma, “Plasticity and toughness in bone,” Phys. Today 62(6), 41–47 (2009). [CrossRef]
Q. Song, S. Xiao, Z. Xu, V. M. Shalaev, and Y. L. Kim, “Random laser spectroscopy for nanoscale perturbation sensing,” Opt. Lett. 35(15), 2624–2626 (2010). [CrossRef] [PubMed]
X. H. Sun, J. Hoon Jeon, J. Blendell, and O. Akkus, “Visualization of a phantom post-yield deformation process in cortical bone,” J. Biomech. 43(10), 1989–1996 (2010). [CrossRef] [PubMed]
H. S. Gupta, W. Wagermaier, G. A. Zickler, D. Raz-Ben Aroush, S. S. Funari, P. Roschger, H. D. Wagner, and P. Fratzl, “Nanoscale deformation mechanisms in bone,” Nano Lett. 5(10), 2108–2111 (2005). [CrossRef] [PubMed]
O. Akkus, “Elastic deformation of mineralized collagen fibrils: an equivalent inclusion based composite model,” J. Biomech. Eng. 127(3), 383–390 (2005). [CrossRef] [PubMed]
K. L. van der Molen, R. W. Tjerkstra, A. P. Mosk, and A. Lagendijk, “Spatial extent of random laser modes,” Phys. Rev. Lett. 98(14), 143901 (2007). [CrossRef] [PubMed]
H. E. Türeci, L. Ge, S. Rotter, and A. D. Stone, “Strong interactions in multimode random lasers,” Science 320(5876), 643–646 (2008). [CrossRef] [PubMed]

Adv. Mater.

R. C. Polson, A. Chipouline, and Z. V. Vardeny, “Random lasing in pi-conjugated films and infiltrated opals,” Adv. Mater. 13(10), 760–764 (2001). [CrossRef]

Appl. Phys. Lett.

R. C. Polson and Z. V. Vardeny, “Random lasing in human tissues,” Appl. Phys. Lett. 85(7), 1289–1291 (2004). [CrossRef]

J. Biomech.

X. H. Sun, J. Hoon Jeon, J. Blendell, and O. Akkus, “Visualization of a phantom post-yield deformation process in cortical bone,” J. Biomech. 43(10), 1989–1996 (2010). [CrossRef] [PubMed]

J. Biomech. Eng.

O. Akkus, “Elastic deformation of mineralized collagen fibrils: an equivalent inclusion based composite model,” J. Biomech. Eng. 127(3), 383–390 (2005). [CrossRef] [PubMed]

J.Phys. A Math. Gen.

H. Cao, “Review on latest developments in random lasers with coherent feedback,” J.Phys. A Math. Gen. 38(49), 10497–10535 (2005). [CrossRef]

Nano Lett.

H. S. Gupta, W. Wagermaier, G. A. Zickler, D. Raz-Ben Aroush, S. S. Funari, P. Roschger, H. D. Wagner, and P. Fratzl, “Nanoscale deformation mechanisms in bone,” Nano Lett. 5(10), 2108–2111 (2005). [CrossRef] [PubMed]

Nat. Phys.

D. S. Wiersma, “The physics and applications of random lasers,” Nat. Phys. 4(5), 359–367 (2008). [CrossRef]
A. Tulek, R. C. Polson, and Z. V. Vardeny, “Naturally occurring resonators in random lasing of pi-conjugated polymer films,” Nat. Phys. 6(4), 303–310 (2010). [CrossRef]

Opt. Lett.

Phys. Rev. A

S. Mujumdar, V. Turck, R. Torre, and D. S. Wiersma, “Chaotic behavior of a random laser with static disorder,” Phys. Rev. A 76(3), 033807 (2007). [CrossRef]
X. Wu, W. Fang, A. Yamilov, A. A. Chabanov, A. A. Asatryan, L. C. Botten, and H. Cao, “Random lasing in weakly scattering systems,” Phys. Rev. A 74(5), 053812 (2006). [CrossRef]

Phys. Rev. B

R. C. Polson and Z. V. Vardeny, “Organic random lasers in the weak-scattering regime,” Phys. Rev. B 71(4), 045205 (2005). [CrossRef]

Phys. Rev. B Condens. Matter

P. Pradhan and N. Kumar, “Localization of light in coherently amplifying random media,” Phys. Rev. B Condens. Matter 50(13), 9644–9647 (1994). [CrossRef] [PubMed]

Phys. Rev. Lett.

H. Cao, Y. G. Zhao, S. T. Ho, E. W. Seelig, Q. H. Wang, and R. P. H. Chang, “Random laser action in semiconductor powder,” Phys. Rev. Lett. 82(11), 2278–2281 (1999). [CrossRef]
C. Vanneste, P. Sebbah, and H. Cao, “Lasing with resonant feedback in weakly scattering random systems,” Phys. Rev. Lett. 98(14), 143902 (2007). [CrossRef] [PubMed]
S. Mujumdar, M. Ricci, R. Torre, and D. S. Wiersma, “Amplified extended modes in random lasers,” Phys. Rev. Lett. 93(5), 053903 (2004). [CrossRef] [PubMed]
K. L. van der Molen, R. W. Tjerkstra, A. P. Mosk, and A. Lagendijk, “Spatial extent of random laser modes,” Phys. Rev. Lett. 98(14), 143901 (2007). [CrossRef] [PubMed]

Phys. Today

R. O. Ritchie, M. J. Buehler, and P. Hansma, “Plasticity and toughness in bone,” Phys. Today 62(6), 41–47 (2009). [CrossRef]

Science

H. E. Türeci, L. Ge, S. Rotter, and A. D. Stone, “Strong interactions in multimode random lasers,” Science 320(5876), 643–646 (2008). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Click here to see a list of articles that cite this paper