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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 5 — Dec. 1, 2010
  • pp: 1502–1513

Diffusing-wave spectroscopy with dynamic contrast variation: disentangling the effects of blood flow and extravascular tissue shearing on signals from deep tissue

Markus Ninck, Markus Untenberger, and Thomas Gisler  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 5, pp. 1502-1513 (2010)
http://dx.doi.org/10.1364/BOE.1.001502


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Abstract

We investigate the effects of blood flow and extravascular tissue shearing on diffusing-wave spectroscopy (DWS) signals from deep tissue, using an ex vivo porcine kidney model perfused artificially at controlled arterial pressure and flow. Temporal autocorrelation functions g(1)(τ) of the multiply scattered light field show a decay which is described by diffusion for constant flow, with a diffusion coefficient scaling linearly with volume flow rate. Replacing blood by a non-scattering fluid reveals a flow-independent background dynamics of the extravascular tissue. For a sinusoidally driven perfusion, field autocorrelation functions g(1)(τ, t′) depend on the phase t′ within the pulsation cycle and are approximately described by diffusion. The effective diffusion coefficient Deff(t′) is modulated at the driving frequency in the presence of blood, showing coupling with flow rate; in the absence of blood, Deff(t′) is modulated at twice the driving frequency, indicating shearing of extravascular tissue as the origin of the DWS signal. For both constant and pulsatile flow the contribution of extravascular tissue shearing to the DWS signal is small.

© 2010 OSA

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.5280) Medical optics and biotechnology : Photon migration
(290.1350) Scattering : Backscattering
(290.1990) Scattering : Diffusion
(290.4210) Scattering : Multiple scattering
(290.7050) Scattering : Turbid media

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: October 1, 2010
Revised Manuscript: November 12, 2010
Manuscript Accepted: November 20, 2010
Published: November 29, 2010

Citation
Markus Ninck, Markus Untenberger, and Thomas Gisler, "Diffusing-wave spectroscopy with dynamic contrast variation: disentangling the effects of blood flow and extravascular tissue shearing on signals from deep tissue," Biomed. Opt. Express 1, 1502-1513 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-5-1502


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