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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 1 — Jan. 1, 2011
  • pp: 194–206

Fluorescence time-resolved imaging system embedded in an ultrasound prostate probe

Aurélie Laidevant, Lionel Hervé, Mathieu Debourdeau, Jérôme Boutet, Nicolas Grenier, and Jean-Marc Dinten  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 1, pp. 194-206 (2011)
http://dx.doi.org/10.1364/BOE.2.000194


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Abstract

Ultrasound imaging (US) of the prostate has a low specificity to distinguish tumors from the surrounding tissues. This limitation leads to systematic biopsies. Fluorescent diffuse optical imaging may represent an innovative approach to guide biopsies to tumors marked with high specificity contrast agents and therefore enable an early detection of prostate cancer. This article describes a time-resolved optical system embedded in a transrectal US probe, as well as the fluorescence reconstruction method and its performance. Optical measurements were performed using a pulsed laser, optical fibers and a time-resolved detection system. A novel fast reconstruction method was derived and used to locate a 45 µL ICG fluorescent inclusion at a concentration of 10 µM, in a liquid prostate phantom. Very high location accuracy (0.15 cm) was achieved after reconstruction, for different positions of the inclusion, in the three directions of space. The repeatability, tested with ten sequential measurements, was of the same order of magnitude. Influence of the input parameters (optical properties and lifetime) is presented. These results confirm the feasibility of using optical imaging for prostate guided biopsies.

© 2010 OSA

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.7050) Medical optics and biotechnology : Turbid media
(300.2530) Spectroscopy : Fluorescence, laser-induced

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: September 28, 2010
Revised Manuscript: December 10, 2010
Manuscript Accepted: December 20, 2010
Published: December 22, 2010

Citation
Aurélie Laidevant, Lionel Hervé, Mathieu Debourdeau, Jérôme Boutet, Nicolas Grenier, and Jean-Marc Dinten, "Fluorescence time-resolved imaging system embedded in an ultrasound prostate probe," Biomed. Opt. Express 2, 194-206 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-1-194


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