OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 1 — Jan. 1, 2011
  • pp: 89–99

Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia

Richard A. Schwarz, Wen Gao, Vanda M. T. Stepanek, Tao T. Le, Vijayashree S. Bhattar, Michelle D. Williams, Jessica K. Wu, Nadarajah Vigneswaran, Karen Adler-Storthz, Ann M. Gillenwater, and Rebecca Richards-Kortum  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 1, pp. 89-99 (2011)
http://dx.doi.org/10.1364/BOE.2.000089


View Full Text Article

Enhanced HTML    Acrobat PDF (1169 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjects, including 28 patients with oral lesions and 5 healthy volunteers, were measured and analyzed. Measurements of 54 nonkeratinized oral sites yielded an area under the receiver operating characteristic curve of 0.90. Measurements of 25 keratinized oral sites yielded an area under the receiver operating characteristic curve of 0.83.

© 2010 OSA

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Optics in Cancer Research

History
Original Manuscript: October 7, 2010
Revised Manuscript: December 3, 2010
Manuscript Accepted: December 6, 2010
Published: December 8, 2010

Citation
Richard A. Schwarz, Wen Gao, Vanda M. T. Stepanek, Tao T. Le, Vijayashree S. Bhattar, Michelle D. Williams, Jessica K. Wu, Nadarajah Vigneswaran, Karen Adler-Storthz, Ann M. Gillenwater, and Rebecca Richards-Kortum, "Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia," Biomed. Opt. Express 2, 89-99 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-1-89


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. B. W. Stewart, and P. Kleihues, eds., World Cancer Report (IARC, 2003), Chap. 5.
  2. S. F. Altekruse, C. L. Kosary, M. Krapcho, N. Neyman, R. Aminou, W. Waldron, J. Ruhl, N. Howlader, Z. Tatalovich, H. Cho, A. Mariotto, M. P. Eisner, D. R. Lewis, K. Cronin, H. S. Chen, E. J. Feuer, D. G. Stinchcomb, and B. K. Edwards, eds., SEER Cancer Statistics Review, 1975–2007 (National Cancer Institute, Bethesda, MD, http://seer.cancer.gov/csr/1975_2007/ , based on November 2009 SEER data submission, posted to the SEER web site, 2010).
  3. A. D. Rapidis, P. Gullane, J. D. Langdon, J. L. Lefebvre, C. Scully, and J. P. Shah, “Major advances in the knowledge and understanding of the epidemiology, aetiopathogenesis, diagnosis, management and prognosis of oral cancer,” Oral Oncol. 45(4-5), 299–300 (2009). [CrossRef] [PubMed]
  4. D. M. Laronde, T. G. Hislop, J. M. Elwood, and M. P. Rosin, “Oral cancer: just the facts,” J. Can. Dent. Assoc. 74(3), 269–272 (2008). [PubMed]
  5. M. P. Rethman, W. Carpenter, E. E. W. Cohen, J. Epstein, C. A. Evans, C. M. Flaitz, F. J. Graham, P. P. Hujoel, J. R. Kalmar, W. M. Koch, P. M. Lambert, M. W. Lingen, B. W. Oettmeier, L. L. Patton, D. Perkins, B. C. Reid, J. J. Sciubba, S. L. Tomar, A. D. Wyatt, K. Aravamudhan, J. Frantsve-Hawley, J. L. Cleveland, D. M. Meyer, and American Dental Association Council on Scientific Affairs Expert Panel on Screening for Oral Squamous Cell Carcinomas, “Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas,” J. Am. Dent. Assoc. 141(5), 509–520 (2010). [PubMed]
  6. J. A. Yellowitz, A. M. Horowitz, T. F. Drury, and H. S. Goodman, “Survey of U.S. dentists’ knowledge and opinions about oral pharyngeal cancer,” J. Am. Dent. Assoc. 131(5), 653–661 (2000). [PubMed]
  7. A. Ariyawardana and L. Ekanayake, “Screening for oral cancer/pre-cancer: knowledge and opinions of dentists employed in the public sector dental services of Sri Lanka,” Asian Pac. J. Cancer Prev. 9(4), 615–618 (2008). [PubMed]
  8. E. Applebaum, T. N. Ruhlen, F. R. Kronenberg, C. Hayes, and E. S. Peters, “Oral cancer knowledge, attitudes and practices: a survey of dentists and primary care physicians in Massachusetts,” J. Am. Dent. Assoc. 140(4), 461–467 (2009). [PubMed]
  9. P. E. Petersen, “Oral cancer prevention and control--the approach of the World Health Organization,” Oral Oncol. 45(4-5), 454–460 (2009). [CrossRef] [PubMed]
  10. S. Fedele, “Diagnostic aids in the screening of oral cancer,” Head Neck Oncol 1(1), 5 (2009). [CrossRef] [PubMed]
  11. L. L. Patton, J. B. Epstein, and A. R. Kerr, “Adjunctive techniques for oral cancer examination and lesion diagnosis: a systematic review of the literature,” J. Am. Dent. Assoc. 139(7), 896–905, quiz 993–994 (2008). [PubMed]
  12. M. W. Lingen, J. R. Kalmar, T. Karrison, and P. M. Speight, “Critical evaluation of diagnostic aids for the detection of oral cancer,” Oral Oncol. 44(1), 10–22 (2008). [CrossRef] [PubMed]
  13. I. J. Bigio and S. G. Bown, “Spectroscopic sensing of cancer and cancer therapy: current status of translational research,” Cancer Biol. Ther. 3(3), 259–267 (2004). [PubMed]
  14. M. G. Müller, T. A. Valdez, I. Georgakoudi, V. Backman, C. Fuentes, S. Kabani, N. Laver, Z. Wang, C. W. Boone, R. R. Dasari, S. M. Shapshay, and M. S. Feld, “Spectroscopic detection and evaluation of morphologic and biochemical changes in early human oral carcinoma,” Cancer 97(7), 1681–1692 (2003). [CrossRef] [PubMed]
  15. D. C. G. de Veld, M. Skurichina, M. J. H. Witjes, R. P. W. Duin, H. J. C. M. Sterenborg, and J. L. N. Roodenburg, “Autofluorescence and diffuse reflectance spectroscopy for oral oncology,” Lasers Surg. Med. 36(5), 356–364 (2005). [CrossRef] [PubMed]
  16. A. Gillenwater, V. Papadimitrakopoulou, and R. Richards-Kortum, “Oral premalignancy: new methods of detection and treatment,” Curr. Oncol. Rep. 8(2), 146–154 (2006). [CrossRef] [PubMed]
  17. P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006). [CrossRef] [PubMed]
  18. I. Pavlova, M. Williams, A. El-Naggar, R. Richards-Kortum, and A. Gillenwater, “Understanding the biological basis of autofluorescence imaging for oral cancer detection: high-resolution fluorescence microscopy in viable tissue,” Clin. Cancer Res. 14(8), 2396–2404 (2008). [CrossRef] [PubMed]
  19. V. R. Kolli, H. E. Savage, T. J. Yao, and S. P. Schantz, “Native cellular fluorescence of neoplastic upper aerodigestive mucosa,” Arch. Otolaryngol. Head Neck Surg. 121(11), 1287–1292 (1995). [PubMed]
  20. J. K. Dhingra, D. F. Perrault, K. McMillan, E. E. Rebeiz, S. Kabani, R. Manoharan, I. Itzkan, M. S. Feld, and S. M. Shapshay, “Early diagnosis of upper aerodigestive tract cancer by autofluorescence,” Arch. Otolaryngol. Head Neck Surg. 122(11), 1181–1186 (1996). [PubMed]
  21. C. S. Betz, M. Mehlmann, K. Rick, H. Stepp, G. Grevers, R. Baumgartner, and A. Leunig, “Autofluorescence imaging and spectroscopy of normal and malignant mucosa in patients with head and neck cancer,” Lasers Surg. Med. 25(4), 323–334 (1999). [CrossRef] [PubMed]
  22. D. L. Heintzelman, U. Utzinger, H. Fuchs, A. Zuluaga, K. Gossage, A. M. Gillenwater, R. Jacob, B. Kemp, and R. R. Richards-Kortum, “Optimal excitation wavelengths for in vivo detection of oral neoplasia using fluorescence spectroscopy,” Photochem. Photobiol. 72(1), 103–113 (2000). [CrossRef] [PubMed]
  23. S. McGee, J. Mirkovic, V. Mardirossian, A. Elackattu, C. C. Yu, S. Kabani, G. Gallagher, R. Pistey, L. Galindo, K. Badizadegan, Z. Wang, R. Dasari, M. S. Feld, and G. Grillone, “Model-based spectroscopic analysis of the oral cavity: impact of anatomy,” J. Biomed. Opt. 13(6), 064034 (2008). [CrossRef] [PubMed]
  24. D. C. G. De Veld, M. J. H. Witjes, H. J. C. M. Sterenborg, and J. L. N. Roodenburg, “The status of in vivo autofluorescence spectroscopy and imaging for oral oncology,” Oral Oncol. 41(2), 117–131 (2005). [CrossRef] [PubMed]
  25. A. Amelink, O. P. Kaspers, H. J. C. M. Sterenborg, J. E. van der Wal, J. L. N. Roodenburg, and M. J. H. Witjes, “Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy,” Oral Oncol. 44(1), 65–71 (2008). [CrossRef] [PubMed]
  26. L. T. Nieman, C. W. Kan, A. Gillenwater, M. K. Markey, and K. Sokolov, “Probing local tissue changes in the oral cavity for early detection of cancer using oblique polarized reflectance spectroscopy: a pilot clinical trial,” J. Biomed. Opt. 13(2), 024011 (2008). [CrossRef] [PubMed]
  27. S. McGee, V. Mardirossian, A. Elackattu, J. Mirkovic, R. Pistey, G. Gallagher, S. Kabani, C. C. Yu, Z. Wang, K. Badizadegan, G. Grillone, and M. S. Feld, “Anatomy-based algorithms for detecting oral cancer using reflectance and fluorescence spectroscopy,” Ann. Otol. Rhinol. Laryngol. 118(11), 817–826 (2009). [PubMed]
  28. S. K. Majumder, A. Gupta, S. Gupta, N. Ghosh, and P. K. Gupta, “Multi-class classification algorithm for optical diagnosis of oral cancer,” J. Photochem. Photobiol. B 85(2), 109–117 (2006). [CrossRef] [PubMed]
  29. R. A. Schwarz, D. Arifler, S. K. Chang, I. Pavlova, I. A. Hussain, V. Mack, B. Knight, R. Richards-Kortum, and A. M. Gillenwater, “Ball lens coupled fiber-optic probe for depth-resolved spectroscopy of epithelial tissue,” Opt. Lett. 30(10), 1159–1161 (2005). [CrossRef] [PubMed]
  30. R. A. Schwarz, W. Gao, D. Daye, M. D. Williams, R. Richards-Kortum, and A. M. Gillenwater, “Autofluorescence and diffuse reflectance spectroscopy of oral epithelial tissue using a depth-sensitive fiber-optic probe,” Appl. Opt. 47(6), 825–834 (2008). [CrossRef] [PubMed]
  31. R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
  32. I. van der Waal, “Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management,” Oral Oncol. 45(4-5), 317–323 (2009). [CrossRef] [PubMed]
  33. P. M. Speight, “Update on oral epithelial dysplasia and progression to cancer,” Head Neck Pathol. 1(1), 61–66 (2007). [CrossRef] [PubMed]
  34. I. Pavlova, C. R. Weber, R. A. Schwarz, M. D. Williams, A. M. Gillenwater, and R. Richards-Kortum, “Fluorescence spectroscopy of oral tissue: Monte Carlo modeling with site-specific tissue properties,” J. Biomed. Opt. 14(1), 014009 (2009). [CrossRef] [PubMed]
  35. K. Huff, P. C. Stark, and L. W. Solomon, “Sensitivity of direct tissue fluorescence visualization in screening for oral premalignant lesions in general practice,” Gen. Dent. 57(1), 34–38 (2009). [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4 Fig. 5
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited