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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 1 — Jan. 1, 2011
  • pp: 89–99

Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia

Richard A. Schwarz, Wen Gao, Vanda M. T. Stepanek, Tao T. Le, Vijayashree S. Bhattar, Michelle D. Williams, Jessica K. Wu, Nadarajah Vigneswaran, Karen Adler-Storthz, Ann M. Gillenwater, and Rebecca Richards-Kortum  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 1, pp. 89-99 (2011)

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A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjects, including 28 patients with oral lesions and 5 healthy volunteers, were measured and analyzed. Measurements of 54 nonkeratinized oral sites yielded an area under the receiver operating characteristic curve of 0.90. Measurements of 25 keratinized oral sites yielded an area under the receiver operating characteristic curve of 0.83.

© 2010 OSA

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Optics in Cancer Research

Original Manuscript: October 7, 2010
Revised Manuscript: December 3, 2010
Manuscript Accepted: December 6, 2010
Published: December 8, 2010

Richard A. Schwarz, Wen Gao, Vanda M. T. Stepanek, Tao T. Le, Vijayashree S. Bhattar, Michelle D. Williams, Jessica K. Wu, Nadarajah Vigneswaran, Karen Adler-Storthz, Ann M. Gillenwater, and Rebecca Richards-Kortum, "Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia," Biomed. Opt. Express 2, 89-99 (2011)

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