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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 10 — Oct. 1, 2011
  • pp: 2792–2803

Raman spectroscopy: a real-time tool for identifying microcalcifications during stereotactic breast core needle biopsies

A. Saha, I. Barman, N. C. Dingari, S. McGee, Z. Volynskaya, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, and M. Fitzmaurice  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 10, pp. 2792-2803 (2011)
http://dx.doi.org/10.1364/BOE.2.002792


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Abstract

Microcalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy. We present here a Raman spectroscopic tool for detecting microcalcifications in breast tissue based on their chemical composition. We collected ex vivo Raman spectra from 159 tissue sites in fresh stereotactic breast needle biopsies from 33 patients, including 54 normal sites, 75 lesions with microcalcifications and 30 lesions without microcalcifications. Application of our Raman technique resulted in a positive predictive value of 97% for detecting microcalcifications. This study shows that Raman spectroscopy has the potential to detect microcalcifications during stereotactic breast core biopsies and provide real-time feedback to radiologists, thus reducing non-diagnostic and false negative biopsies.

© 2011 OSA

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(300.6450) Spectroscopy : Spectroscopy, Raman
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: August 18, 2011
Revised Manuscript: September 9, 2011
Manuscript Accepted: September 13, 2011
Published: September 14, 2011

Citation
A. Saha, I. Barman, N. C. Dingari, S. McGee, Z. Volynskaya, L. H. Galindo, W. Liu, D. Plecha, N. Klein, R. R. Dasari, and M. Fitzmaurice, "Raman spectroscopy: a real-time tool for identifying microcalcifications during stereotactic breast core needle biopsies," Biomed. Opt. Express 2, 2792-2803 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-10-2792


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