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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 11 — Nov. 1, 2011
  • pp: 2926–2933

Method of targeted delivery of laser beam to isolated retinal rods by fiber optics

Nigel Sim, Dmitri Bessarab, C. Michael Jones, and Leonid Krivitsky  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 11, pp. 2926-2933 (2011)
http://dx.doi.org/10.1364/BOE.2.002926


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Abstract

A method of controllable light delivery to retinal rod cells using an optical fiber is described. Photo-induced current of the living rod cells was measured with the suction electrode technique. The approach was tested with measurements relating the spatial distribution of the light intensity to photo-induced current. In addition, the ion current responses of rod cells to polarized light at two different orientation geometries of the cells were studied.

© 2011 OSA

OCIS Codes
(330.0330) Vision, color, and visual optics : Vision, color, and visual optics
(330.5310) Vision, color, and visual optics : Vision - photoreceptors
(330.5380) Vision, color, and visual optics : Physiology
(330.7331) Vision, color, and visual optics : Visual optics, receptor optics

ToC Category:
Vision, Color, and Visual Optics

History
Original Manuscript: September 7, 2011
Revised Manuscript: September 29, 2011
Manuscript Accepted: September 29, 2011
Published: September 30, 2011

Citation
Nigel Sim, Dmitri Bessarab, C. Michael Jones, and Leonid Krivitsky, "Method of targeted delivery of laser beam to isolated retinal rods by fiber optics," Biomed. Opt. Express 2, 2926-2933 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-11-2926


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References

  1. J. E. Dowling, The Retina (Harvard University Press, Cambridge, Massachusetts, 1987).
  2. F. Rieke and D. A. Baylor, “Single-photon detection by rod cells of the retina,” Rev. Mod. Phys.70(3), 1027–1036 (1998). [CrossRef]
  3. S. Hecht, S. Shlaer, and M. H. Pirenne, “Energy, quanta and vision,” J. Gen. Physiol.25(6), 819–840 (1942). [CrossRef] [PubMed]
  4. D. A. Baylor, T. D. Lamb, and K.-W. Yau, “The membrane current of single rod outer segments,” J. Physiol.288, 589–611 (1979). [PubMed]
  5. D. A. Baylor, T. D. Lamb, and K.-W. Yau, “Responses of retinal rods to single photons,” J. Physiol.288, 613–634 (1979). [PubMed]
  6. P. B. Detwiler, J. D. Conner, and R. D. Bodoia, “Gigaseal patch clamp recordings from outer segments of intact retinal rods,” Nature300(5887), 59–61 (1982). [CrossRef] [PubMed]
  7. A. L. Hodgkin, P. A. McNaughton, B. J. Nunn, and K. W. Yau, “Effect of ions on retinal rods from Bufo marinus,” J. Physiol.350, 649–680 (1984). [PubMed]
  8. E. N. Pugh, Jr. and T. D. Lamb, “Phototransduction in vertebrate rods and cones: molecular mechanisms of amplification, recovery and light adaptation,” in Molecular Mechanisms of Visual Transduction, Vol. 3. of Handbook of Biological Physics, D. G. Stavenga, W. J. de Grip, and E. N. Pugh, Jr., eds. (Elsevier science, 2000), Chap. 5, pp. 183–255.
  9. W. H. Xiong and K.-W. Yau, “Rod sensitivity during Xenopus development,” J. Gen. Physiol.120(6), 817–827 (2002). [CrossRef] [PubMed]
  10. J. L. Schnapf, “Dependence of the single photon response on longitudinal position of absorption in toad rod outer segments,” J. Physiol.343, 147–159 (1983). [PubMed]
  11. V. I. Govardovskii, D. A. Korenyak, S. A. Shukolyukov, and L. V. Zueva, “Lateral diffusion of rhodopsin in photoreceptor membrane: a reappraisal,” Mol. Vis.15, 1717–1729 (2009). [PubMed]
  12. D. A. Baylor and R. Fettiplace, “Light path and photon capture in turtle photoreceptors,” J. Physiol.248(2), 433–464 (1975). [PubMed]
  13. F. I. Hárosi, “Absorption spectra and linear dichroism of some amphibian photoreceptors,” J. Gen. Physiol.66(3), 357–382 (1975). [CrossRef] [PubMed]
  14. D. A. Baylor, B. J. Nunn, and J. L. Schnapf, “The photocurrent, noise and spectral sensitivity of rods of the monkey Macaca fascicularis,” J. Physiol.357, 575–607 (1984). [PubMed]
  15. G. Horvath and D. Varju, Polarized Light in Animal Vision (Springer-Verlag, Berlin, 2004).
  16. N. W. Roberts and M. G. Needham, “A mechanism of polarized light sensitivity in cone photoreceptors of the goldfish Carassius auratus,” Biophys. J.93(9), 3241–3248 (2007). [CrossRef] [PubMed]
  17. F. L. Tobey and J. M. Enoch, “Directionality and waveguide properties of optically isolated rat rods,” Invest. Ophthalmol.12(12), 873–880 (1973). [PubMed]
  18. A. Koskelainen, K. Donner, G. Kalamkarov, and S. Hemilä, “Changes in the light-sensitive current of salamander rods upon manipulation of putative pH-regulating mechanisms in the inner and outer segment,” Vision Res.34(8), 983–994 (1994). [CrossRef] [PubMed]
  19. W. A. Shurkliff, Polarized Light (Harvard University Press, Cambridge, Massachusetts, 1962).
  20. T. D. Lamb, P. A. McNaughton, and K.-W. Yau, “Spatial spread of activation and background desensitization in toad rod outer segments,” J. Physiol.319, 463–496 (1981). [PubMed]
  21. A. Dhatak and K. Thyagarajan, Introduction to Fiber Optics (Cambridge University Press, Cambridge, UK, 1998).

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