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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 11 — Nov. 1, 2011
  • pp: 2995–3009

Spectroscopic-speckle variance OCT for microvasculature detection and analysis

Xuan Liu, Kang Zhang, Yong Huang, and Jin U. Kang  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 11, pp. 2995-3009 (2011)

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We propose and studied optical coherence tomography (OCT) combining spectroscopic (SOCT) and speckle variance (svOCT) functions to effectively detect locations of microvasculatures and assess blood oxygen saturation level. Chorioallantoic membrane of a chick embryo was imaged in vivo to perform the analysis of the system. We also studied the effect of speckle in spectral domain using experimental data and performed time-averaging to reduce speckle noise locally. We combined SOCT and svOCT images using hue, saturation and value (HSV) color map to show the localized spectroscopic property of blood. Results show distinct spectroscopic properties between arterial blood and capillary blood.

© 2011 OSA

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Optical Coherence Tomography

Original Manuscript: June 24, 2011
Revised Manuscript: September 29, 2011
Manuscript Accepted: October 2, 2011
Published: October 4, 2011

Xuan Liu, Kang Zhang, Yong Huang, and Jin U. Kang, "Spectroscopic-speckle variance OCT for microvasculature detection and analysis," Biomed. Opt. Express 2, 2995-3009 (2011)

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