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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 11 — Nov. 1, 2011
  • pp: 3072–3078

Thermal intravascular photoacoustic imaging

Bo Wang and Stanislav Emelianov  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 11, pp. 3072-3078 (2011)

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Intravascular photoacoustics (IVPA)—a minimally invasive imaging technique with contrast related to optical absorption properties of tissue, can be used to visualize atherosclerotic plaques. However, the amplitude of photoacoustic signals is also related to a temperature dependent, tissue specific parameter—the Grüneisen parameter. Therefore, photoacoustic signals measured at different temperatures may reveal information about tissue composition. In this study, thermal IVPA (tIVPA) imaging was introduced. The imaging studies were performed using an ex vivo atherosclerotic rabbit aorta. Temperature dependent photoacoustic responses from lipid in plaques and lipid in periadventitial tissue were different, thus allowing tIVPA images to delineate the location of lipid-rich plaques. The results indicate that tIVPA imaging has a potential to characterize tissue composition in atherosclerotic vessels.

© 2011 OSA

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Photoacoustic Imaging and Spectroscopy

Original Manuscript: August 2, 2011
Revised Manuscript: September 30, 2011
Manuscript Accepted: October 3, 2011
Published: October 13, 2011

Bo Wang and Stanislav Emelianov, "Thermal intravascular photoacoustic imaging," Biomed. Opt. Express 2, 3072-3078 (2011)

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