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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 12 — Dec. 1, 2011
  • pp: 3232–3247

Corneal topography from spectral optical coherence tomography (sOCT)

Sergio Ortiz, Damian Siedlecki, Pablo Pérez-Merino, Noelia Chia, Alberto de Castro, Maciej Szkulmowski, Maciej Wojtkowski, and Susana Marcos  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 12, pp. 3232-3247 (2011)

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We present a method to obtain accurate corneal topography from a spectral optical coherence tomography (sOCT) system. The method includes calibration of the device, compensation of the fan (or field) distortion introduced by the scanning architecture, and image processing analysis for volumetric data extraction, segmentation and fitting. We present examples of three-dimensional (3-D) surface topography measurements on spherical and aspheric lenses, as well as on 10 human corneas in vivo. Results of sOCT surface topography (with and without fan-distortion correction) were compared with non-contact profilometry (taken as reference) on a spherical lens, and with non-contact profilometry and state-of-the art commercial corneal topography instruments on aspheric lenses and on subjects. Corneal elevation maps from all instruments were fitted by quadric surfaces (as well as by tenth-order Zernike polynomials) using custom routines. We found that the discrepancy in the estimated radius of curvature from nominal values in artificial corneas decreased from 4.6% (without fan distortion correction) to 1.6% (after fan distortion correction), and the difference in the asphericity decreased from 130% to 5%. In human corneas, the estimated corneal radius of curvature was not statistically significantly different across instruments. However, a Bland-Altman analysis showed consistent differences in the estimated asphericity and corneal shape between sOCT topographies without fan distortion correction and the rest of the measurements.

© 2011 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(110.6880) Imaging systems : Three-dimensional image acquisition
(120.4640) Instrumentation, measurement, and metrology : Optical instruments
(120.4800) Instrumentation, measurement, and metrology : Optical standards and testing
(120.6650) Instrumentation, measurement, and metrology : Surface measurements, figure
(330.7327) Vision, color, and visual optics : Visual optics, ophthalmic instrumentation

ToC Category:
Optical Coherence Tomography

Original Manuscript: September 7, 2011
Revised Manuscript: October 20, 2011
Manuscript Accepted: October 20, 2011
Published: November 4, 2011

Sergio Ortiz, Damian Siedlecki, Pablo Pérez-Merino, Noelia Chia, Alberto de Castro, Maciej Szkulmowski, Maciej Wojtkowski, and Susana Marcos, "Corneal topography from spectral optical coherence tomography (sOCT)," Biomed. Opt. Express 2, 3232-3247 (2011)

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