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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 12 — Dec. 1, 2011
  • pp: 3267–3277

Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging

Metasebya Solomon, Brian R. White, Ralph E. Nothdruft, Walter Akers, Gail Sudlow, Adam T. Eggebrecht, Samuel Achilefu, and Joseph P. Culver  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 12, pp. 3267-3277 (2011)
http://dx.doi.org/10.1364/BOE.2.003267


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Abstract

We have developed a fiber-based, video-rate fluorescence diffuse optical tomography (DOT) system for noninvasive in vivo sentinel lymph node (SLN) mapping. Concurrent acquisition of fluorescence and reference signals allowed the efficient generation of ratio-metric data for 3D image reconstruction. Accurate depth localization and high sensitivity to fluorescent targets were established in to depths of >10 mm. In vivo accumulation of indocyanine green (ICG) dye was imaged in the region of the SLN following intradermal injection into the forepaw of rats. These results suggest that video-rate fluorescence DOT has significant potential as a clinical tool for noninvasive mapping of SLN.

© 2011 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5270) Medical optics and biotechnology : Photon density waves
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Diffuse Optical Imaging

History
Original Manuscript: August 1, 2011
Revised Manuscript: September 15, 2011
Manuscript Accepted: September 18, 2011
Published: November 8, 2011

Virtual Issues
Advances in Optics for Biotechnology, Medicine, and Surgery (2011) Biomedical Optics Express

Citation
Metasebya Solomon, Brian R. White, Ralph E. Nothdruft, Walter Akers, Gail Sudlow, Adam T. Eggebrecht, Samuel Achilefu, and Joseph P. Culver, "Video-rate fluorescence diffuse optical tomography for in vivo sentinel lymph node imaging," Biomed. Opt. Express 2, 3267-3277 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-12-3267


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