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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 12 — Dec. 1, 2011
  • pp: 3309–3320

Improving wavefront boundary condition for in vivo high resolution adaptive optics ophthalmic imaging

Weiyao Zou, Xiaofeng Qi, Gang Huang, and Stephen A. Burns  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 12, pp. 3309-3320 (2011)

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An ophthalmic adaptive optics (AO) imaging system is especially affected by pupil edge effects due to the higher noise and aberration level at the edge of the human pupil as well as the impact of head and eye motions on the pupil. In this paper, a two-step approach was proposed and implemented for reducing the edge effects and improving wavefront slope boundary condition. First, given an imaging pupil, a smaller size of sampling aperture can be adopted to avoid the noisy boundary slope data. To do this, we calibrated a set of influence matrices for different aperture sizes to accommodate pupil variations within the population. In step two, the slope data was extrapolated from the less noisy slope data inside the pupil towards the outside such that we had reasonable slope data over a larger aperture to stabilize the impact of eye pupil dynamics. This technique is applicable to any Neumann boundary-based active /adaptive modality but it is especially useful in the eye for improving AO retinal image quality where the boundary positions fluctuate.

© 2011 OSA

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(170.1790) Medical optics and biotechnology : Confocal microscopy
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices
(220.1080) Optical design and fabrication : Active or adaptive optics

ToC Category:
Active and Adaptive Optics

Original Manuscript: August 31, 2011
Revised Manuscript: November 3, 2011
Manuscript Accepted: November 8, 2011
Published: November 10, 2011

Weiyao Zou, Xiaofeng Qi, Gang Huang, and Stephen A. Burns, "Improving wavefront boundary condition for in vivo high resolution adaptive optics ophthalmic imaging," Biomed. Opt. Express 2, 3309-3320 (2011)

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