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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 2 — Feb. 1, 2011
  • pp: 271–277

On-chip spectrophotometry for bioanalysis using microring resonators

Arthur Nitkowski, Antje Baeumner, and Michal Lipson  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 2, pp. 271-277 (2011)

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We measure optical absorption in color-producing enzymatic reactions for biochemical analysis with a microscale optofluidic device. Cavity-enhanced laser spectrophotometry is performed on analytes within a microfluidic channel at visible wavelengths with silicon nitride microring resonators of 100 µm radius and quality factor of ~180,000. The resonator transmission spectrum is analyzed to determine optical absorption with a detection limit of 0.12 cm−1. The device can be used to detect the activity of individual enzymes in a few minutes within a 100 fL sensing volume. The high sensitivity, small footprint, and low analyte consumption make absorption-based microring resonators attractive for lab-on-a-chip applications.

© 2011 OSA

OCIS Codes
(130.6010) Integrated optics : Sensors
(300.6550) Spectroscopy : Spectroscopy, visible
(140.3948) Lasers and laser optics : Microcavity devices

ToC Category:
Biosensors and Molecular Diagnostics

Original Manuscript: November 18, 2010
Revised Manuscript: December 23, 2010
Manuscript Accepted: December 27, 2010
Published: January 5, 2011

Arthur Nitkowski, Antje Baeumner, and Michal Lipson, "On-chip spectrophotometry for bioanalysis using microring resonators," Biomed. Opt. Express 2, 271-277 (2011)

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