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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 2 — Feb. 1, 2011
  • pp: 291–304

Vapor bubble generation around gold nano-particles and its application to damaging of cells

M. Kitz, S. Preisser, A. Wetterwald, M. Jaeger, G. N. Thalmann, and M. Frenz  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 2, pp. 291-304 (2011)

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We investigated vapor bubbles generated upon irradiation of gold nanoparticles with nanosecond laser pulses. Bubble formation was studied both with optical and acoustic means on supported single gold nanoparticles and single nanoparticles in suspension. Formation thresholds determined at different wavelengths indicate a bubble formation efficiency increasing with the irradiation wavelength. Vapor bubble generation in Bac-1 cells containing accumulations of the same particles was also investigated at different wavelengths. Similarly, they showed an increasing cell damage efficiency for longer wavelengths. Vapor bubbles generated by single laser pulses were about half the cell size when inducing acute damage.

© 2011 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.5180) Medical optics and biotechnology : Photodynamic therapy

ToC Category:
Optical Therapies and Photomodificaton

Original Manuscript: October 11, 2010
Revised Manuscript: December 7, 2010
Manuscript Accepted: January 9, 2011
Published: January 11, 2011

M. Kitz, S. Preisser, A. Wetterwald, M. Jaeger, G. N. Thalmann, and M. Frenz, "Vapor bubble generation around gold nano-particles and its application to damaging of cells," Biomed. Opt. Express 2, 291-304 (2011)

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