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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 2 — Feb. 1, 2011
  • pp: 385–396

Magneto-photo-acoustic imaging

Min Qu, Srivalleesha Mallidi, Mohammad Mehrmohammadi, Ryan Truby, Kimberly Homan, Pratixa Joshi, Yun-Sheng Chen, Konstantin Sokolov, and Stanislav Emelianov  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 2, pp. 385-396 (2011)
http://dx.doi.org/10.1364/BOE.2.000385


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Abstract

Magneto-photo-acoustic imaging, a technique based on the synergy of magneto-motive ultrasound, photoacoustic and ultrasound imaging, is introduced. Hybrid nanoconstructs, liposomes encapsulating gold nanorods and iron oxide nanoparticles, were used as a dual-contrast agent for magneto-photo-acoustic imaging. Tissue-mimicking phantom and macrophage cells embedded in ex vivo porcine tissue were used to demonstrate that magneto-photo-acoustic imaging is capable of visualizing the location of cells or tissues labeled with dual-contrast nanoparticles with sufficient contrast, excellent contrast resolution and high spatial resolution in the context of the anatomical structure of the surrounding tissues. Therefore, magneto-photo-acoustic imaging is capable of identifying the nanoparticle-labeled pathological regions from the normal tissue, providing a promising platform to noninvasively diagnose and characterize pathologies.

© 2011 OSA

OCIS Codes
(110.7170) Imaging systems : Ultrasound
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Multimodal Imaging

History
Original Manuscript: September 30, 2010
Revised Manuscript: December 7, 2010
Manuscript Accepted: January 14, 2011
Published: January 21, 2011

Citation
Min Qu, Srivalleesha Mallidi, Mohammad Mehrmohammadi, Ryan Truby, Kimberly Homan, Pratixa Joshi, Yun-Sheng Chen, Konstantin Sokolov, and Stanislav Emelianov, "Magneto-photo-acoustic imaging," Biomed. Opt. Express 2, 385-396 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-2-385


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