OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 2 — Feb. 1, 2011
  • pp: 385–396

Optics InfoBase > Biomedical Optics Express > Volume 2 > Issue 2 > Page 385

Magneto-photo-acoustic imaging

Min Qu, Srivalleesha Mallidi, Mohammad Mehrmohammadi, Ryan Truby, Kimberly Homan, Pratixa Joshi, Yun-Sheng Chen, Konstantin Sokolov, and Stanislav Emelianov  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 2, pp. 385-396 (2011)
http://dx.doi.org/10.1364/BOE.2.000385


View Full Text Article

Enhanced HTML    Acrobat PDF (1073 KB)


Advanced Search

Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Magneto-photo-acoustic imaging, a technique based on the synergy of magneto-motive ultrasound, photoacoustic and ultrasound imaging, is introduced. Hybrid nanoconstructs, liposomes encapsulating gold nanorods and iron oxide nanoparticles, were used as a dual-contrast agent for magneto-photo-acoustic imaging. Tissue-mimicking phantom and macrophage cells embedded in ex vivo porcine tissue were used to demonstrate that magneto-photo-acoustic imaging is capable of visualizing the location of cells or tissues labeled with dual-contrast nanoparticles with sufficient contrast, excellent contrast resolution and high spatial resolution in the context of the anatomical structure of the surrounding tissues. Therefore, magneto-photo-acoustic imaging is capable of identifying the nanoparticle-labeled pathological regions from the normal tissue, providing a promising platform to noninvasively diagnose and characterize pathologies.

© 2011 OSA

OCIS Codes
(110.7170) Imaging systems : Ultrasound
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Multimodal Imaging

History
Original Manuscript: September 30, 2010
Revised Manuscript: December 7, 2010
Manuscript Accepted: January 14, 2011
Published: January 21, 2011

Citation
Min Qu, Srivalleesha Mallidi, Mohammad Mehrmohammadi, Ryan Truby, Kimberly Homan, Pratixa Joshi, Yun-Sheng Chen, Konstantin Sokolov, and Stanislav Emelianov, "Magneto-photo-acoustic imaging," Biomed. Opt. Express 2, 385-396 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-2-385


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. F. S. Foster, G. R. Lockwood, L. K. Ryan, K. A. Harasiewicz, L. Berube, and A. M. Rauth, “Principles and applications of ultrasound backscatter microscopy,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 40(5), 608–617 (1993). [CrossRef] [PubMed]
  2. S. Y. Emelianov, S. R. Aglyamov, A. B. Karpiouk, S. Mallidi, S. Park, S. Sethuraman, J. Shah, R. W. Smalling, J. M. Rubin, and W. G. Scott, “Synergy and applications of combined ultrasound, elasticity, and photoacoustic imaging,” in Proceedings of IEEE Ultrasonics Symposium (Institute of Electrical and Electronics Engineers, 2006), pp. 405–415.
  3. A. G. Bell, “On the production and reproduction of sound by light,” Am. J. Sci. 20, 305–324 (1880).
  4. R. A. Kruger and P. Liu, “Photoacoustic ultrasound: pulse production and detection of 0.5% Liposyn,” Med. Phys. 21(7), 1179–1184 (1994). [CrossRef] [PubMed]
  5. A. A. Oraevsky, S. L. Jacques, R. O. Esenaliev, and F. K. Tittel, “Laser-based optoacoustic imaging in biological tissues,” Proc. SPIE 2134A, 122–128 (1994).
  6. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003). [CrossRef] [PubMed]
  7. S. Mallidi, T. Larson, J. Aaron, K. Sokolov, and S. Emelianov, “Molecular specific optoacoustic imaging with plasmonic nanoparticles,” Opt. Express 15(11), 6583–6588 (2007). [CrossRef] [PubMed]
  8. S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009). [CrossRef] [PubMed]
  9. J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology 17(16), 4183–4190 (2006). [CrossRef]
  10. M. Mehrmohammadi, L. M. J. Oh, E. Yantsen, T. Larson, S. Mallidi, S. Park, K. P. Johnston, K. Sokolov, T. Milner, and S. Emelianov, “Imaging of iron oxide nanoparticles using magneto-motive ultrasound,” in Proceedings of IEEE Ultrasonics Symposium (Institute of Electrical and Electronics Engineers, 2007), pp. 652–655.
  11. M. Mehrmohammadi, J. Oh, L. Ma, S. Roo, E. Yantsen, S. Mallidi, K. P. Johnston, K. Sokolov, T. E. Milner, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging,” in Proceedings of 25th Annual Houston Conference on Biomedical Engineering Research (Kluwer Academic, 2008), p. 75.
  12. M. Mehrmohammadi, S. R. Aglyamov, A. B. Karpiouk, J. Oh, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound to assess viscoelastic properties of soft tissues,” in Proceedings of the Seventh International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity (International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, 2008), p. 106.
  13. M. Mehrmohammadi, L. L. Ma, Y. Chen, M. Qu, P. Joshi, R. M. Chen, K. P. Johnston, and S. Emelianov, “Combined photothermal therapy and magneto-motive ultrasound imaging using multifunctional nanoparticles,” Proc. SPIE 7574(757405), 757405, 757405–8 (2010).
  14. K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett. 33(9), 929–931 (2008). [CrossRef] [PubMed]
  15. J. A. Copland, M. Eghtedari, V. L. Popov, N. Kotov, N. Mamedova, M. Motamedi, and A. A. Oraevsky, “Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography,” Mol. Imaging Biol. 6(5), 341–349 (2004). [CrossRef] [PubMed]
  16. C. Loo, A. Lin, L. Hirsch, M. H. Lee, J. Barton, N. Halas, J. West, and R. Drezek, “Nanoshell-enabled photonics-based imaging and therapy of cancer,” Technol. Cancer Res. Treat. 3(1), 33–40 (2004). [PubMed]
  17. X. Yang, S. E. Skrabalak, Z. Y. Li, Y. Xia, and L. V. Wang, “Photoacoustic tomography of a rat cerebral cortex in vivo with au nanocages as an optical contrast agent,” Nano Lett. 7(12), 3798–3802 (2007). [CrossRef] [PubMed]
  18. P. K. Jain, S. Eustis, and M. A. El-Sayed, “Plasmon coupling in nanorod assemblies: optical absorption, discrete dipole approximation simulation, and exciton-coupling model,” J. Phys. Chem. B 110(37), 18243–18253 (2006). [CrossRef] [PubMed]
  19. A. B. Karpiouk, S. R. Aglyamov, Y. A. Ilinskii, E. A. Zabolotskaya, and S. Y. Emelianov, “Assessment of shear modulus of tissue using ultrasound radiation force acting on a spherical acoustic inhomogeneity,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 56(11), 2380–2387 (2009). [CrossRef] [PubMed]
  20. R. L. Truby, K. A. Homan, M. Qu, M. Mehrmohammadi, and S. Emelianov, “Synthesis of a hybrid plasmonic-superparamagnetic contrast agent for magneto-photo-acoustic imaging,” presented at the Biomecial Engineering Society 2010 Annual Meeting, Austin, Tex., Oct. 6–9, 2010).
  21. B. Nikoobakht and M. A. El-Sayed, “Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method,” Chem. Mater. 15(10), 1957–1962 (2003). [CrossRef]
  22. C. Wang, J. Chen, T. Talavage, and J. Irudayaraj, ““““Gold nanorod/Fe3O4 nanoparticle “nano-pearl-necklaces” for simutaneous targeting, dual-mode imaging, and photothermal ablation of cancer cells,” Angew. Chem. Int. Ed. 48(15), 2759–2763 (2009). [CrossRef]
  23. M. A. Lubinski, S. Y. Emelianov, and M. O’Donnell, “Speckle tracking methods for ultrasonic elasticity imaging using short-time correlation,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 46(1), 82–96 (1999). [CrossRef] [PubMed]
  24. Q. Wei, H. M. Song, A. P. Leonov, J. A. Hale, D. Oh, Q. K. Ong, K. Ritchie, and A. Wei, “Gyromagnetic imaging: dynamic optical contrast using gold nanostars with magnetic cores,” J. Am. Chem. Soc. 131(28), 9728–9734 (2009). [CrossRef] [PubMed]
  25. C. Xu, J. Xie, D. Ho, C. Wang, N. Kohler, E. G. Walsh, J. R. Morgan, Y. E. Chin, and S. Sun, “Au-Fe3O4 dumbbell nanoparticles as dual-functional probes,” Angew. Chem. Int. Ed. Engl. 47(1), 173–176 (2008). [CrossRef] [PubMed]
  26. P. P. Joshi, Y. Chen, S. Kim, J. Shah, K. Sokolov, and S. Emelianov, “Molecular therapeutic agents for noninvasive photoacoustic image-guided photothermal therapy,” in Conference Proceedings—IEEE Engineering in Medicine and Biology Society (Institute of Electrical and Electronics Engineers, 2009), pp. 4106–4109.

Cited By

 Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited