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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 3 — Mar. 1, 2011
  • pp: 520–533

Influence of tissue absorption and scattering on the depth dependent sensitivity of Raman fiber probes investigated by Monte Carlo simulations

Carina Reble, Ingo Gersonde, Chad A. Lieber, and Jürgen Helfmann  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 3, pp. 520-533 (2011)

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We present a Monte Carlo model, which we use to calculate the depth dependent sensitivity or sampling volume of different single fiber and multi-fiber Raman probes. A two-layer skin model is employed to investigate the dependency of the sampling volume on the absorption and reduced scattering coefficients in the near infrared wavelength range (NIR). The shape of the sampling volume is mainly determined by the scattering coefficient and the wavelength dependency of absorption and scattering has only a small effect on the sampling volume of a typical fingerprint spectrum. An increase in the sampling depth in nonmelanoma skin cancer, compared to normal skin, is obtained.

© 2011 OSA

OCIS Codes
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5660) Medical optics and biotechnology : Raman spectroscopy

ToC Category:
Spectroscopic Diagnostics

Original Manuscript: November 20, 2010
Revised Manuscript: January 30, 2011
Manuscript Accepted: February 2, 2011
Published: February 7, 2011

Carina Reble, Ingo Gersonde, Chad A. Lieber, and Jürgen Helfmann, "Influence of tissue absorption and scattering on the depth dependent sensitivity of Raman fiber probes investigated by Monte Carlo simulations," Biomed. Opt. Express 2, 520-533 (2011)

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