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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 3 — Mar. 1, 2011
  • pp: 634–644

Dual modality fluorescence confocal and spectral-domain optical coherence tomography microendoscope

Houssine Makhlouf, Andrew R. Rouse, and Arthur F. Gmitro  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 3, pp. 634-644 (2011)

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Optical biopsy facilitates in vivo disease diagnoses by providing a real-time in situ view of tissue in a clinical setting. Fluorescence confocal microendoscopy and optical coherence tomography (OCT) are two methods that have demonstrated significant potential in this context. These techniques provide complementary viewpoints. The high resolution and contrast associated with confocal systems allow en face visualization of sub-cellular details and cellular organization within a thin layer of biological tissue. OCT provides cross-sectional images showing the tissue micro-architecture to a depth beyond the reach of confocal systems. We present a novel design for a bench-top imaging system that incorporates both confocal and OCT modalities in the same optical train allowing the potential for rapid switching between the two imaging techniques. Preliminary results using simple phantoms show that it is possible to realize both confocal microendoscopy and OCT through a fiber bundle based imaging system.

© 2011 OSA

OCIS Codes
(110.2350) Imaging systems : Fiber optics imaging
(110.4500) Imaging systems : Optical coherence tomography
(170.1610) Medical optics and biotechnology : Clinical applications
(170.1790) Medical optics and biotechnology : Confocal microscopy
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Endoscopes, Catheters and Micro-Optics

Original Manuscript: December 2, 2010
Revised Manuscript: January 18, 2011
Manuscript Accepted: February 15, 2011
Published: February 22, 2011

Houssine Makhlouf, Andrew R. Rouse, and Arthur F. Gmitro, "Dual modality fluorescence confocal and spectral-domain optical coherence tomography microendoscope," Biomed. Opt. Express 2, 634-644 (2011)

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