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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 3 — Mar. 1, 2011
  • pp: 705–716

Functional tomography using a time-gated ICCD camera

Qing Zhao, Lorenzo Spinelli, Andrea Bassi, Gianluca Valentini, Davide Contini, Alessandro Torricelli, Rinaldo Cubeddu, Giovanni Zaccanti, Fabrizio Martelli, and Antonio Pifferi  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 3, pp. 705-716 (2011)

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We present a system for near infrared functional tomography based on a single pulsed source and a time-gated camera, for non-contact collection over a large area. The mean penetration depth of diffusely reflected photons is dependent on the arrival time of photons, but not on the source–detector distance. Thus, time-encoded data can be used to recover depth information while photon exiting point is exploited for lateral localization. This approach was tested against simulations, demonstrating both detection and localization capabilities. Preliminary measurements on inhomogeneous phantoms showed good detection sensibility, even for a low optical perturbation, and localization capabilities, yet with decreasing spatial resolution for increasing depths. Potential application of this method to in vivo functional studies on the brain is discussed.

© 2011 OSA

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Diffuse Optical Imaging

Original Manuscript: December 23, 2010
Revised Manuscript: February 18, 2011
Manuscript Accepted: February 19, 2011
Published: February 25, 2011

Qing Zhao, Lorenzo Spinelli, Andrea Bassi, Gianluca Valentini, Davide Contini, Alessandro Torricelli, Rinaldo Cubeddu, Giovanni Zaccanti, Fabrizio Martelli, and Antonio Pifferi, "Functional tomography using a time-gated ICCD camera," Biomed. Opt. Express 2, 705-716 (2011)

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