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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 4 — Apr. 1, 2011
  • pp: 1007–1020

Optical mammography combined with fluorescence imaging: lesion detection using scatterplots

Anaïs Leproux, Marjolein van der Voort, Martin B. van der Mark, Rik Harbers, Stephanie M. W. Y. van de Ven, and Ton G. van Leeuwen  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 4, pp. 1007-1020 (2011)

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Using scatterplots of 2 or 3 parameters, diffuse optical tomography and fluorescence imaging are combined to improve detectability of breast lesions. Small or low contrast phantom-lesions that were missed in the optical and fluorescence images were detected in the scatterplots. In patient measurements, all tumors were visible and easily differentiated from artifacts and areolas in the scatterplots. The different rate of intake and wash out of the fluorescent contrast agent in the healthy versus malignant tissues was also observed in the scatterplot: this information can be used to discriminate malignant lesion from normal structures.

© 2011 OSA

OCIS Codes
(170.3830) Medical optics and biotechnology : Mammography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Optics in Cancer Research

Original Manuscript: March 4, 2011
Revised Manuscript: March 24, 2011
Manuscript Accepted: March 25, 2011
Published: March 30, 2011

Anaïs Leproux, Marjolein van der Voort, Martin B. van der Mark, Rik Harbers, Stephanie M. W. Y. van de Ven, and Ton G. van Leeuwen, "Optical mammography combined with fluorescence imaging: lesion detection using scatterplots," Biomed. Opt. Express 2, 1007-1020 (2011)

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