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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 4 — Apr. 1, 2011
  • pp: 1021–1029

Correction for spatial averaging in laser speckle contrast analysis

Oliver Thompson, Michael Andrews, and Evan Hirst  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 4, pp. 1021-1029 (2011)
http://dx.doi.org/10.1364/BOE.2.001021


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Abstract

Practical laser speckle contrast analysis systems face a problem of spatial averaging of speckles, due to the pixel size in the cameras used. Existing practice is to use a system factor in speckle contrast analysis to account for spatial averaging. The linearity of the system factor correction has not previously been confirmed. The problem of spatial averaging is illustrated using computer simulation of time-integrated dynamic speckle, and the linearity of the correction confirmed using both computer simulation and experimental results. The valid linear correction allows various useful compromises in the system design.

© 2011 OSA

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(110.6150) Imaging systems : Speckle imaging
(170.0110) Medical optics and biotechnology : Imaging systems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology

ToC Category:
Optics of Tissue and Turbid Media

History
Original Manuscript: February 28, 2011
Revised Manuscript: March 22, 2011
Manuscript Accepted: March 25, 2011
Published: March 30, 2011

Virtual Issues
In vivo Microcirculation Imaging (2011) Biomedical Optics Express

Citation
Oliver Thompson, Michael Andrews, and Evan Hirst, "Correction for spatial averaging in laser speckle contrast analysis," Biomed. Opt. Express 2, 1021-1029 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-4-1021


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References

  1. A. Fercher and J. Briers, “Flow visualization by means of single-exposure speckle photography,” Opt. Commun. 37(5), 326–330 (1981). [CrossRef]
  2. J. Briers and S. Webster, “Laser speckle contrast analysis (LASCA): a nonscanning, full-field technique for monitoring capillary blood flow,” J. Biomed. Opt. 1(2), 174–179 (1996). [CrossRef]
  3. O. B. Thompson and M. K. Andrews, “Tissue perfusion measurements: multiple-exposure laser speckle analysis generates laser Doppler-like spectra,” J. Biomed. Opt. 15(2), 027015 (2010). [CrossRef] [PubMed]
  4. A. B. Parthasarathy, W. J. Tom, A. Gopal, X. Zhang, and A. K. Dunn, “Robust flow measurement with multi-exposure speckle imaging,” Opt. Express 16(3), 1975–1989 (2008). [CrossRef] [PubMed]
  5. P. F. Almoro, J. Glückstad, and S. G. Hanson, “Single-plane multiple speckle pattern phase retrieval using a deformable mirror,” Opt. Express 18(18), 19304–19313 (2010). [CrossRef] [PubMed]
  6. E. Kolenović and W. Osten, “Estimation of the phase error in interferometric measurements by evaluation of the speckle field intensity,” Appl. Opt. 46(24), 6096–6104 (2007). [CrossRef] [PubMed]
  7. J. W. Goodman, “Statistical properties of laser speckle patterns,” in Laser Speckle and Related Phenomena, J.C. Dainty, ed. (Springer-Verlag, 1975).
  8. D. D. Duncan and S. J. Kirkpatrick, “Can laser speckle flowmetry be made a quantitative tool?” J. Opt. Soc. Am. A 25(8), 2088–2094 (2008). [CrossRef] [PubMed]
  9. A. Ennos, “Speckle interferometry,” in Laser Speckle and Related Phenomena, J.C. Dainty, ed. (Springer-Verlag, 1975).
  10. B. Choi, J. Ramirez-San-Juan, and J. Nelson, “Characterization of a laser speckle imaging instrument for monitoring skin blood flow dynamics,” Proc. SPIE 5686, 36–40 (2005). [CrossRef]
  11. S. Yuan, A. Devor, D. A. Boas, and A. K. Dunn, “Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging,” Appl. Opt. 44(10), 1823–1830 (2005). [CrossRef] [PubMed]
  12. S. J. Kirkpatrick, D. D. Duncan, and E. M. Wells-Gray, “Detrimental effects of speckle-pixel size matching in laser speckle contrast imaging,” Opt. Lett. 33(24), 2886–2888 (2008). [CrossRef] [PubMed]
  13. D. Duncan and S. Kirkpatrick, “Algorithms for simulation of speckle (laser and otherwise),” Proc. SPIE 6855, 685505 (2008). [CrossRef]
  14. J. Briers and X. He, “Laser speckle contrast analysis (LASCA) for blood flow visualization: Improved image processing,” Proc. SPIE 3252, 26–33 (1998). [CrossRef]
  15. B. Choi, N. M. Kang, and J. S. Nelson, “Laser speckle imaging for monitoring blood flow dynamics in the in vivo rodent dorsal skin fold model,” Microvasc. Res. 68(2), 143–146 (2004). [CrossRef] [PubMed]
  16. http://www.ondaxinc.com/stabilized_laser.htm
  17. R. B. Saager, C. Kondru, K. Au, K. Sry, F. Ayers, and A. J. Durkin, “Multilayer silicone phantoms for the evaluation of quantitative optical techniques in skin imaging,” Proc. SPIE 7567, 756706 (2010). [CrossRef]

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