Real-time intraoperative 4D full-range FD-OCT based on the dual graphics processing units architecture for microsurgery guidance

doi:10.1364/BOE.2.000764

Real-time intraoperative 4D full-range FD-OCT based on the dual graphics processing units architecture for microsurgery guidance

Kang Zhang and Jin U. Kang »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 4, pp. 764-770 (2011)
http://dx.doi.org/10.1364/BOE.2.000764

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Abstract

Real-time 4D full-range complex-conjugate-free Fourier-domain optical coherence tomography (FD-OCT) is implemented using a dual graphics processing units (dual-GPUs) architecture. One GPU is dedicated to the FD-OCT data processing while the second one is used for the volume rendering and display. GPU accelerated non-uniform fast Fourier transform (NUFFT) is also implemented to suppress the side lobes of the point spread function to improve the image quality. Using a 128,000 A-scan/second OCT spectrometer, we obtained 5 volumes/second real-time full-range 3D OCT imaging. A complete micro-manipulation of a phantom using a microsurgical tool is monitored by multiple volume renderings of the same 3D date set with different view angles. Compared to the conventional surgical microscope, this technology would provide the surgeons a more comprehensive spatial view of the microsurgical site and could serve as an effective intraoperative guidance tool.

OCIS Codes
(100.2000) Image processing : Digital image processing
(100.6890) Image processing : Three-dimensional image processing
(110.4500) Imaging systems : Optical coherence tomography
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: December 8, 2010
Revised Manuscript: February 25, 2011
Manuscript Accepted: February 25, 2011
Published: March 1, 2011

Citation
Kang Zhang and Jin U. Kang, "Real-time intraoperative 4D full-range FD-OCT based on the dual graphics processing units architecture for microsurgery guidance," Biomed. Opt. Express 2, 764-770 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-4-764

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References

K. Zhang, W. Wang, J. Han, and J. U. Kang, “A surface topology and motion compensation system for microsurgery guidance and intervention based on common-path optical coherence tomography,” IEEE Trans. Biomed. Eng. 56(9), 2318–2321 (2009). [CrossRef] [PubMed]
Y. K. Tao, J. P. Ehlers, C. A. Toth, and J. A. Izatt, “Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery,” Opt. Lett. 35(20), 3315–3317 (2010). [CrossRef] [PubMed]
A. Stephen, Boppart, Mark E. Brezinski and James G. Fujimoto, “Surgical guidance and intervention,” in Handbook of Optical Coherence Tomography, B. E. Bouma and G. J Tearney, ed. (Marcel Dekker, New York, NY, 2001).
W.-Y. Oh, B. J. Vakoc, M. Shishkov, G. J. Tearney, and B. E. Bouma, “>400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging,” Opt. Lett. 35(17), 2919–2921 (2010). [CrossRef] [PubMed]
B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010). [CrossRef] [PubMed]
W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010). [CrossRef] [PubMed]
T. Bonin, G. Franke, M. Hagen-Eggert, P. Koch, and G. Hüttmann, “In vivo Fourier-domain full-field OCT of the human retina with 1.5 million A-lines/s,” Opt. Lett. 35(20), 3432–3434 (2010). [CrossRef] [PubMed]
K. Zhang and J. U. Kang, “Real-time 4D signal processing and visualization using graphics processing unit on a regular nonlinear-k Fourier-domain OCT system,” Opt. Express 18(11), 11772–11784 (2010). [CrossRef] [PubMed]
M. Sylwestrzak, M. Szkulmowski, D. Szlag, and P. Targowski, “Real-time imaging for spectral optical coherence tomography with massively parallel data processing,” Photonics Lett. Poland 2(3), 137–139 (2010).
J. Probst, D. Hillmann, E. Lankenau, C. Winter, S. Oelckers, P. Koch, and G. Hüttmann, “Optical coherence tomography with online visualization of more than seven rendered volumes per second,” J. Biomed. Opt. 15(2), 026014 (2010). [CrossRef] [PubMed]
K. Zhang and J. U. Kang, “Graphics processing unit accelerated non-uniform fast Fourier transform for ultrahigh-speed, real-time Fourier-domain OCT,” Opt. Express 18(22), 23472–23487 (2010). [CrossRef] [PubMed]
Y. Watanabe, S. Maeno, K. Aoshima, H. Hasegawa, and H. Koseki, “Real-time processing for full-range Fourier-domain optical-coherence tomography with zero-filling interpolation using multiple graphic processing units,” Appl. Opt. 49(25), 4756–4762 (2010). [CrossRef] [PubMed]
B. Baumann, M. Pircher, E. Götzinger, and C. K. Hitzenberger, “Full range complex spectral domain optical coherence tomography without additional phase shifters,” Opt. Express 15(20), 13375–13387 (2007), http://www.opticsinfobase.org/abstract.cfm?URI=oe-15-20-13375 . [CrossRef] [PubMed]
NVIDIA, “NVIDIA CUDA C Programming Guide Version 3.2” (2010).

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[1] K. Zhang, W. Wang, J. Han, and J. U. Kang, “A surface topology and motion compensation system for microsurgery guidance and intervention based on common-path optical coherence tomography,” IEEE Trans. Biomed. Eng. 56(9), 2318–2321 (2009). [CrossRef] [PubMed]

[2] Y. K. Tao, J. P. Ehlers, C. A. Toth, and J. A. Izatt, “Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery,” Opt. Lett. 35(20), 3315–3317 (2010). [CrossRef] [PubMed]

[3] A. Stephen, Boppart, Mark E. Brezinski and James G. Fujimoto, “Surgical guidance and intervention,” in Handbook of Optical Coherence Tomography, B. E. Bouma and G. J Tearney, ed. (Marcel Dekker, New York, NY, 2001).

[4] W.-Y. Oh, B. J. Vakoc, M. Shishkov, G. J. Tearney, and B. E. Bouma, “>400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging,” Opt. Lett. 35(17), 2919–2921 (2010). [CrossRef] [PubMed]

[5] B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010). [CrossRef] [PubMed]

[6] W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010). [CrossRef] [PubMed]

[7] T. Bonin, G. Franke, M. Hagen-Eggert, P. Koch, and G. Hüttmann, “In vivo Fourier-domain full-field OCT of the human retina with 1.5 million A-lines/s,” Opt. Lett. 35(20), 3432–3434 (2010). [CrossRef] [PubMed]

[8] K. Zhang and J. U. Kang, “Real-time 4D signal processing and visualization using graphics processing unit on a regular nonlinear-k Fourier-domain OCT system,” Opt. Express 18(11), 11772–11784 (2010). [CrossRef] [PubMed]

[9] M. Sylwestrzak, M. Szkulmowski, D. Szlag, and P. Targowski, “Real-time imaging for spectral optical coherence tomography with massively parallel data processing,” Photonics Lett. Poland 2(3), 137–139 (2010).

[10] J. Probst, D. Hillmann, E. Lankenau, C. Winter, S. Oelckers, P. Koch, and G. Hüttmann, “Optical coherence tomography with online visualization of more than seven rendered volumes per second,” J. Biomed. Opt. 15(2), 026014 (2010). [CrossRef] [PubMed]

[11] K. Zhang and J. U. Kang, “Graphics processing unit accelerated non-uniform fast Fourier transform for ultrahigh-speed, real-time Fourier-domain OCT,” Opt. Express 18(22), 23472–23487 (2010). [CrossRef] [PubMed]

[12] Y. Watanabe, S. Maeno, K. Aoshima, H. Hasegawa, and H. Koseki, “Real-time processing for full-range Fourier-domain optical-coherence tomography with zero-filling interpolation using multiple graphic processing units,” Appl. Opt. 49(25), 4756–4762 (2010). [CrossRef] [PubMed]

[13] B. Baumann, M. Pircher, E. Götzinger, and C. K. Hitzenberger, “Full range complex spectral domain optical coherence tomography without additional phase shifters,” Opt. Express 15(20), 13375–13387 (2007), http://www.opticsinfobase.org/abstract.cfm?URI=oe-15-20-13375 . [CrossRef] [PubMed]

[14] NVIDIA, “NVIDIA CUDA C Programming Guide Version 3.2” (2010).

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Biomedical Optics Express

Real-time intraoperative 4D full-range FD-OCT based on the dual graphics processing units architecture for microsurgery guidance