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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 4 — Apr. 1, 2011
  • pp: 946–965

Hyperspectral image reconstruction for diffuse optical tomography

Fridrik Larusson, Sergio Fantini, and Eric L. Miller  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 4, pp. 946-965 (2011)

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We explore the development and performance of algorithms for hyperspectral diffuse optical tomography (DOT) for which data from hundreds of wavelengths are collected and used to determine the concentration distribution of chromophores in the medium under investigation. An efficient method is detailed for forming the images using iterative algorithms applied to a linearized Born approximation model assuming the scattering coefficient is spatially constant and known. The L-surface framework is employed to select optimal regularization parameters for the inverse problem. We report image reconstructions using 126 wavelengths with estimation error in simulations as low as 0.05 and mean square error of experimental data of 0.18 and 0.29 for ink and dye concentrations, respectively, an improvement over reconstructions using fewer specifically chosen wavelengths.

© 2011 OSA

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3830) Medical optics and biotechnology : Mammography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography
(290.1990) Scattering : Diffusion
(290.7050) Scattering : Turbid media

ToC Category:
Image Reconstruction and Inverse Problems

Original Manuscript: February 11, 2011
Revised Manuscript: March 10, 2011
Manuscript Accepted: March 10, 2011
Published: March 25, 2011

Fridrik Larusson, Sergio Fantini, and Eric L. Miller, "Hyperspectral image reconstruction for diffuse optical tomography," Biomed. Opt. Express 2, 946-965 (2011)

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