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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 4 — Apr. 1, 2011
  • pp: 966–979

Effects of arterial blood gas levels on cerebral blood flow and oxygen transport

S. J. Payne, J. Mohammad, M. M. Tisdall, and I. Tachtsidis  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 4, pp. 966-979 (2011)
http://dx.doi.org/10.1364/BOE.2.000966


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Abstract

Near Infra-Red Spectroscopy (NIRS) is a non-invasive technique which can be used to investigate cerebral haemodynamics and oxygenation with high temporal resolution. When combined with measures of Cerebral Blood Flow (CBF), it has the potential to provide information about oxygen delivery, utilization and metabolism. However, the interpretation of experimental results is complex. Measured NIRS signals reflect both scalp and cerebral haemodynamics and are influenced by many factors. The relationship between Arterial Blood Pressure (ABP) and CBF has been widely investigated and it central to cerebral autoregulation. Changes in arterial blood gas levels have a significant effect on ABP and CBF and these relationships have been quantified previously. The relationship between ABP and NIRS signals, however, has not been fully characterized. In this paper, we thus investigate the influence of changes in arterial blood gas levels both experimentally and theoretically, using an extended mathematical model of cerebral blood flow and metabolism, in terms of the phase angle at 0.1 Hz. The autoregulation response is found to be strongly dependent upon the carbon dioxide (CO2) partial pressure but much less so upon changes in arterial oxygen saturation (SaO2). The results for phase angle sensitivity to CO2 show good agreement between experimental and theory, but a poorer agreement is found for the sensitivity to SaO2.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5380) Medical optics and biotechnology : Physiology

ToC Category:
Neuroscience and Brain Imaging

History
Original Manuscript: December 20, 2010
Revised Manuscript: February 25, 2011
Manuscript Accepted: March 7, 2011
Published: March 25, 2011

Citation
S. J. Payne, J. Mohammad, M. M. Tisdall, and I. Tachtsidis, "Effects of arterial blood gas levels on cerebral blood flow and oxygen transport," Biomed. Opt. Express 2, 966-979 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-4-966


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