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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 5 — May. 1, 2011
  • pp: 1097–1105

Method for comparing visual field defects to local RNFL and RGC damage seen on frequency domain OCT in patients with glaucoma.

Donald C. Hood and Ali S. Raza  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 5, pp. 1097-1105 (2011)

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To relate structural (anatomical) and functional (behavioral) measures of glaucomatous damage, a method is described for comparing visual field defects to local retinal ganglion cell (RGC) and retinal nerve fiber layer (RNFL) thicknesses. Thickness maps of the RNFL and the RGC + inner plexiform layer, obtained with frequency domain optical coherence tomography (fdOCT), were transformed into probability maps by comparing them to a normative group. As demonstrated in patients with glaucomatous damage to the macula, the probability map associated with the patient’s visual field can be directly compared to the fdOCT probability maps by taking into consideration the displacement of the RGCs.

© 2011 OSA

OCIS Codes
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(330.4300) Vision, color, and visual optics : Vision system - noninvasive assessment

ToC Category:
Ophthalmology Applications

Original Manuscript: February 25, 2011
Revised Manuscript: March 28, 2011
Manuscript Accepted: March 28, 2011
Published: April 5, 2011

Virtual Issues
Cellular Imaging of the Retina (2011) Biomedical Optics Express

Donald C. Hood and Ali S. Raza, "Method for comparing visual field defects to local RNFL and RGC damage seen on frequency domain OCT in patients with glaucoma.," Biomed. Opt. Express 2, 1097-1105 (2011)

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991). [CrossRef] [PubMed]
  2. J. S. Schuman, M. R. Hee, A. V. Arya, T. Pedut-Kloizman, C. A. Puliafito, J. G. Fujimoto, and E. A. Swanson, “Optical coherence tomography: a new tool for glaucoma diagnosis,” Curr. Opin. Ophthalmol. 6(2), 89–95 (1995). [PubMed]
  3. M. Wang, D. C. Hood, J.-S. Cho, Q. Ghadiali, C. V. De Moraes, X. Zhang, R. Ritch, and J. M. Liebmann, “Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography,” Arch. Ophthalmol. 127(7), 875–881 (2009). [CrossRef] [PubMed]
  4. O. Tan, V. Chopra, A. T. Lu, J. S. Schuman, H. Ishikawa, G. Wollstein, R. Varma, and D. Huang, “Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography,” Ophthalmology 116(12), 2305–2314.e2, (2009). [CrossRef] [PubMed]
  5. A. S. Raza, J. Cho, C. G. V. De Moraes, M. Wang, X. Zhang, R. H. Kardon, J. M. Liebmann, R. Ritch, and D. C. Hood, “Macular retinal ganglion cell layer thickness and local visual field sensitivity in glaucoma,” Arch. Ophthalmol. (to be published).
  6. N. R. Kim, E. S. Lee, G. J. Seong, J. H. Kim, H. G. An, and C. Y. Kim, “Structure-function relationship and diagnostic value of macular ganglion cell complex measurement using Fourier-domain OCT in glaucoma,” Invest. Ophthalmol. Vis. Sci. 51(9), 4646–4651 (2010). [CrossRef] [PubMed]
  7. J. W. Cho, K. R. Sung, S. Lee, S. C. Yun, S. Y. Kang, J. Choi, J. H. Na, Y. Lee, and M. S. Kook, “Relationship between visual field sensitivity and macular ganglion cell complex thickness as measured by spectral-domain optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(12), 6401–6407 (2010). [CrossRef] [PubMed]
  8. D. C. Hood, A. S. Raza, C. G. V. de Moraes, J. G. Odel, V. C. Greenstein, J. M. Liebmann, and R. Ritch, “Initial arcuate defects within the central 10 degrees in glaucoma,” Invest. Ophthalmol. Vis. Sci. 52(2), 940–946 (2011). [CrossRef] [PubMed]
  9. Q. Yang, C. A. Reisman, Z. Wang, Y. Fukuma, M. Hangai, N. Yoshimura, A. Tomidokoro, M. Araie, A. S. Raza, D. C. Hood, and K. Chan, “Automated layer segmentation of macular OCT images using dual-scale gradient information,” Opt. Express 18(20), 21293–21307 (2010). [CrossRef] [PubMed]
  10. N. Drasdo, C. L. Millican, C. R. Katholi, and C. A. Curcio, “The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field,” Vision Res. 47(22), 2901–2911 (2007). [CrossRef] [PubMed]
  11. D. C. Hood and V. C. Greenstein, “Multifocal VEP and ganglion cell damage: applications and limitations for the study of glaucoma,” Prog. Retin. Eye Res. 22(2), 201–251 (2003). [CrossRef] [PubMed]

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