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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 5 — May. 1, 2011
  • pp: 1115–1120

Model for measurement of water layer thickness under lipid bilayers by surface plasmon resonance

Koyo Watanabe  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 5, pp. 1115-1120 (2011)

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A multilayered-substrate model is proposed for surface plasmon resonance (SPR)-based measurement of the thickness of a water layer sandwiched between a lipid bilayer and an underlying support. To calculate sensitivity, a 473 nm-wavelength excitation source and a silver layer are used for the SPR sensor. It is theoretically shown that the multilayered substrate design achieves sufficient sensitivity for such measurements and that sensitivity is enhanced with a SiO2 layer of appropriate thickness and a buffer solution of high refractive index.

© 2011 OSA

OCIS Codes
(120.6650) Instrumentation, measurement, and metrology : Surface measurements, figure
(240.6680) Optics at surfaces : Surface plasmons
(310.4165) Thin films : Multilayer design

ToC Category:
Optical Biophysics

Original Manuscript: January 24, 2011
Revised Manuscript: April 3, 2011
Manuscript Accepted: April 4, 2011
Published: April 7, 2011

Koyo Watanabe, "Model for measurement of water layer thickness under lipid bilayers by surface plasmon resonance," Biomed. Opt. Express 2, 1115-1120 (2011)

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