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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 5 — May. 1, 2011
  • pp: 1121–1134

Fiber optic microendoscopy for preclinical study of bacterial infection dynamics

Nooman Mufti, Ying Kong, Jeffrey D. Cirillo, and Kristen C. Maitland  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 5, pp. 1121-1134 (2011)
http://dx.doi.org/10.1364/BOE.2.001121


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Abstract

We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 µm resolution, a 750 µm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guérin (BCG) bacteria were detected in situ from inocula down to 104 and 107 colony forming units, respectively.

© 2011 OSA

OCIS Codes
(060.2350) Fiber optics and optical communications : Fiber optics imaging
(110.0110) Imaging systems : Imaging systems
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Endoscopes, Catheters and Micro-Optics

History
Original Manuscript: February 23, 2011
Revised Manuscript: April 2, 2011
Manuscript Accepted: April 4, 2011
Published: April 7, 2011

Citation
Nooman Mufti, Ying Kong, Jeffrey D. Cirillo, and Kristen C. Maitland, "Fiber optic microendoscopy for preclinical study of bacterial infection dynamics," Biomed. Opt. Express 2, 1121-1134 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-5-1121


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