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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 5 — May. 1, 2011
  • pp: 1194–1203

Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa

Saam Motamedi, Tuya Shilagard, Kert Edward, Luke Koong, Suimin Qui, and Gracie Vargas  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 5, pp. 1194-1203 (2011)
http://dx.doi.org/10.1364/BOE.2.001194


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Abstract

We explore the feasibility of using gold nanorods with efficient two-photon luminescence properties as contrast agents for intravital imaging of neoplasia. This investigation spanned ex vivo characterization in cells/tissue to in vivo implementation in an oral carcinogenesis model. GNRs were >40 times brighter than surrounding tissue. Intravital imaging revealed 3D microvasculature, and in dysplasia, abnormal vessels (dense and tortuous) compared to normal. GNRs were diffusely distributed in lesions after 24 hours. No known previous study has revealed abnormal vessel structure in dysplasia by imaging. Results suggest GNRs can function as high-contrast agents for in vivo visualization of carcinogenesis features.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(160.4236) Materials : Nanomaterials
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Nanotechnology and Plasmonics

History
Original Manuscript: January 4, 2011
Revised Manuscript: April 8, 2011
Manuscript Accepted: April 11, 2011
Published: April 13, 2011

Citation
Saam Motamedi, Tuya Shilagard, Kert Edward, Luke Koong, Suimin Qui, and Gracie Vargas, "Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa," Biomed. Opt. Express 2, 1194-1203 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-5-1194


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