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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 5 — May. 1, 2011
  • pp: 1394–1402

Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties

Jussi Kinnunen, Simo Saarakkala, Markku Hauta-Kasari, Pasi Vahimaa, and Jukka S. Jurvelin  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 5, pp. 1394-1402 (2011)
http://dx.doi.org/10.1364/BOE.2.001394


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Abstract

The information from spectral reflectance of articular cartilage has been related to the integrity of the tissue. This study explores more in detail the interrelations between the cartilage composition, structure and mechanical properties, and optical spectral reflectance. Using human osteochondral samples the reflectance spectral images of articular cartilage were captured and analyzed by using CIELAB color space as well as principal component analysis. With both analysis methods statistically significant correlations were observed between the reflectance and histological integrity, as assessed by Mankin scoring, tissue proteoglycan content and dynamic modulus. In thick human cartilage, the reflectance was found to be independent of the cartilage thickness, suggesting negligible influence of the underlying subchondral bone. Based on the present results diagnostically relevant information on cartilage quality can be extracted using optical spectral reflectance measurements. These measurements could be feasible during arthroscopic surgery when more in-depth information of the properties of articular cartilage is needed.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(300.6550) Spectroscopy : Spectroscopy, visible
(330.1730) Vision, color, and visual optics : Colorimetry

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: February 9, 2011
Revised Manuscript: April 21, 2011
Manuscript Accepted: April 21, 2011
Published: April 29, 2011

Citation
Jussi Kinnunen, Simo Saarakkala, Markku Hauta-Kasari, Pasi Vahimaa, and Jukka S. Jurvelin, "Optical spectral reflectance of human articular cartilage – relationships with tissue structure, composition and mechanical properties," Biomed. Opt. Express 2, 1394-1402 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-5-1394


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