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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 6 — Jun. 1, 2011
  • pp: 1524–1538

Robust automatic segmentation of corneal layer boundaries in SDOCT images using graph theory and dynamic programming

Francesco LaRocca, Stephanie J. Chiu, Ryan P. McNabb, Anthony N. Kuo, Joseph A. Izatt, and Sina Farsiu  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 6, pp. 1524-1538 (2011)
http://dx.doi.org/10.1364/BOE.2.001524


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Abstract

Segmentation of anatomical structures in corneal images is crucial for the diagnosis and study of anterior segment diseases. However, manual segmentation is a time-consuming and subjective process. This paper presents an automatic approach for segmenting corneal layer boundaries in Spectral Domain Optical Coherence Tomography images using graph theory and dynamic programming. Our approach is robust to the low-SNR and different artifact types that can appear in clinical corneal images. We show that our method segments three corneal layer boundaries in normal adult eyes more accurately compared to an expert grader than a second grader—even in the presence of significant imaging outliers.

© 2011 OSA

OCIS Codes
(100.0100) Image processing : Image processing
(100.2960) Image processing : Image analysis
(110.4500) Imaging systems : Optical coherence tomography
(170.4470) Medical optics and biotechnology : Ophthalmology

ToC Category:
Image Processing

History
Original Manuscript: March 8, 2011
Revised Manuscript: May 6, 2011
Manuscript Accepted: May 10, 2011
Published: May 12, 2011

Citation
Francesco LaRocca, Stephanie J. Chiu, Ryan P. McNabb, Anthony N. Kuo, Joseph A. Izatt, and Sina Farsiu, "Robust automatic segmentation of corneal layer boundaries in SDOCT images using graph theory and dynamic programming," Biomed. Opt. Express 2, 1524-1538 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-6-1524


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References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991). [CrossRef] [PubMed]
  2. J. G. Fujimoto, W. Drexler, J. S. Schuman, and C. K. Hitzenberger, “Optical Coherence Tomography (OCT) in ophthalmology: introduction,” Opt. Express 17(5), 3978–3979 (2009). [CrossRef] [PubMed]
  3. J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography,” Arch. Ophthalmol. 112(12), 1584–1589 (1994). [PubMed]
  4. S. Radhakrishnan, A. M. Rollins, J. E. Roth, S. Yazdanfar, V. Westphal, D. S. Bardenstein, and J. A. Izatt, “Real-time optical coherence tomography of the anterior segment at 1310 nm,” Arch. Ophthalmol. 119(8), 1179–1185 (2001). [PubMed]
  5. Y. Morad, E. Sharon, L. Hefetz, and P. Nemet, “Corneal thickness and curvature in normal-tension glaucoma,” Am. J. Ophthalmol. 125(2), 164–168 (1998). [CrossRef] [PubMed]
  6. Z. Liu and S. C. Pflugfelder, “The effects of long-term contact lens wear on corneal thickness, curvature, and surface regularity,” Ophthalmology 107(1), 105–111 (2000). [CrossRef] [PubMed]
  7. Z. Liu, A. J. Huang, and S. C. Pflugfelder, “Evaluation of corneal thickness and topography in normal eyes using the Orbscan corneal topography system,” Br. J. Ophthalmol. 83(7), 774–778 (1999). [CrossRef] [PubMed]
  8. L. J. Müller, E. Pels, and G. F. J. M. Vrensen, “The specific architecture of the anterior stroma accounts for maintenance of corneal curvature,” Br. J. Ophthalmol. 85(4), 437–443 (2001). [CrossRef] [PubMed]
  9. B. Seitz, F. Torres, A. Langenbucher, A. Behrens, and E. Suárez, “Posterior corneal curvature changes after myopic laser in situ keratomileusis,” Ophthalmology 108(4), 666–672, discussion 673 (2001). [CrossRef] [PubMed]
  10. M. Shimmyo, A. J. Ross, A. Moy, and R. Mostafavi, “Intraocular pressure, Goldmann applanation tension, corneal thickness, and corneal curvature in Caucasians, Asians, Hispanics, and African Americans,” Am. J. Ophthalmol. 136(4), 603–613 (2003). [CrossRef] [PubMed]
  11. M. Kohlhaas, A. G. Boehm, E. Spoerl, A. Pürsten, H. J. Grein, and L. E. Pillunat, “Effect of central corneal thickness, corneal curvature, and axial length on applanation tonometry,” Arch. Ophthalmol. 124(4), 471–476 (2006). [CrossRef] [PubMed]
  12. Y. Li, R. Shekhar, and D. Huang, “Segmentation of 830- and 1310-nm LASIK corneal optical coherence tomography images,” Proc. SPIE 4684, 167–178 (2002). [CrossRef]
  13. Y. Li, R. Shekhar, and D. Huang, “Corneal pachymetry mapping with high-speed optical coherence tomography,” Ophthalmology 113(5), 792–799.e2 (2006). [CrossRef] [PubMed]
  14. Y. Li, M. V. Netto, R. Shekhar, R. R. Krueger, and D. Huang, “A longitudinal study of LASIK flap and stromal thickness with high-speed optical coherence tomography,” Ophthalmology 114(6), 1124–1132e1 (2007). [CrossRef] [PubMed]
  15. J. A. Eichel, A. K. Mishra, D. A. Clausi, P. W. Fieguth, and K. K. Bizheva, “A novel algorithm for extraction of the layers of the cornea,” in Canadian Conference on Computer and Robot Vision,2009. CRV '09 (IEEE, 2009), pp. 313–320.
  16. N. Hutchings, T. L. Simpson, C. Hyun, A. A. Moayed, S. Hariri, L. Sorbara, and K. Bizheva, “Swelling of the human cornea revealed by high-speed, ultrahigh-resolution optical coherence tomography,” Invest. Ophthalmol. Vis. Sci. 51(9), 4579–4584 (2010). [CrossRef] [PubMed]
  17. M. Haeker, M. Sonka, R. Kardon, V. A. Shah, X. Wu, and M. D. Abramoff, “Automated segmentation of intraretinal layers from macular optical coherence tomography images,” Proc. SPIE 6512, 651214 (2007). [CrossRef]
  18. M. K. Garvin, M. D. Abràmoff, X. Wu, S. R. Russell, T. L. Burns, and M. Sonka, “Automated 3-D intraretinal layer segmentation of macular spectral-domain optical coherence tomography images,” IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009). [CrossRef] [PubMed]
  19. K. Lee, M. Niemeijer, M. K. Garvin, Y. H. Kwon, M. Sonka, and M. D. Abramoff, “Segmentation of the optic disc in 3-D OCT scans of the optic nerve head,” IEEE Trans. Med. Imaging 29(1), 159–168 (2010). [CrossRef] [PubMed]
  20. D. A. Tolliver, I. Koutis, H. Ishikawa, J. S. Schuman, and G. L. Miller, “Automatic multiple retinal layer segmentation in spectral domain OCT scans via spectral rounding,” Invest. Ophthalmol. Vis. Sci. 49, 1878-2222 (2008).
  21. S. J. Chiu, X. T. Li, P. Nicholas, C. A. Toth, J. A. Izatt, and S. Farsiu, “Automatic segmentation of seven retinal layers in SDOCT images congruent with expert manual segmentation,” Opt. Express 18(18), 19413–19428 (2010). [CrossRef] [PubMed]
  22. M. Zhao, A. N. Kuo, and J. A. Izatt, “3D refraction correction and extraction of clinical parameters from spectral domain optical coherence tomography of the cornea,” Opt. Express 18(9), 8923–8936 (2010). [CrossRef] [PubMed]
  23. E. W. Dijkstra, “A note on two problems in connexion with graphs,” Numer. Math. 1(1), 269–271 (1959). [CrossRef]
  24. R. Szeliski, “Image alignment and stitching: a tutorial,” Found. Trends Comput. Graphics Vision 2(1), 1–104 (2006). [CrossRef]
  25. L. W. Herndon, S. A. Choudhri, T. Cox, K. F. Damji, M. B. Shields, and R. R. Allingham, “Central corneal thickness in normal, glaucomatous, and ocular hypertensive eyes,” Arch. Ophthalmol. 115(9), 1137–1141 (1997). [PubMed]
  26. H. F. Li, W. M. Petroll, T. Møller-Pedersen, J. K. Maurer, H. D. Cavanagh, and J. V. Jester, “Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing (CMTF),” Curr. Eye Res. 16(3), 214–221 (1997). [CrossRef] [PubMed]
  27. D. Z. Reinstein, R. H. Silverman, M. J. Rondeau, and D. J. Coleman, “Epithelial and corneal thickness measurements by high-frequency ultrasound digital signal processing,” Ophthalmology 101(1), 140–146 (1994). [PubMed]
  28. S. G. Schuman, A. F. Koreishi, S. Farsiu, S. H. Jung, J. A. Izatt, and C. A. Toth, “Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography,” Ophthalmology 116(3), 488–496e2 (2009). [CrossRef] [PubMed]
  29. D. Z. Reinstein, T. J. Archer, M. Gobbe, R. H. Silverman, and D. J. Coleman, “Epithelial thickness in the normal cornea: three-dimensional display with Artemis very high-frequency digital ultrasound,” J. Refract. Surg. 24(6), 571–581 (2008). [PubMed]

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