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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 6 — Jun. 1, 2011
  • pp: 1539–1552

Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT

Bernhard Baumann, Benjamin Potsaid, Martin F. Kraus, Jonathan J. Liu, David Huang, Joachim Hornegger, Alex E. Cable, Jay S. Duker, and James G. Fujimoto  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 6, pp. 1539-1552 (2011)
http://dx.doi.org/10.1364/BOE.2.001539


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Abstract

Doppler OCT provides depth-resolved information on flow in biological tissues. In this article, we demonstrate ultrahigh speed swept source/Fourier domain OCT for visualization and quantitative assessment of retinal blood flow. Using swept laser technology, the system operated in the 1050-nm wavelength range at a high axial scan rate of 200 kHz. The rapid imaging speed not only enables volumetric imaging with high axial scan densities, but also enables measurement of high flow velocities in the central retinal vessels. Deep penetration in the optic nerve and lamina cribrosa was achieved by imaging at 1-µm wavelengths. By analyzing en-face images extracted from 3D Doppler data sets, absolute flow in single vessels as well as total retinal blood flow was measured using a simple and robust protocol that does not require measurement of Doppler angles. The results from measurements in healthy eyes suggest that ultrahigh speed swept source/Fourier domain OCT could be a promising technique for volumetric imaging of retinal vasculature and quantitation of retinal blood flow in a wide range of retinal diseases.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(280.2490) Remote sensing and sensors : Flow diagnostics

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: March 16, 2011
Revised Manuscript: May 11, 2011
Manuscript Accepted: May 11, 2011
Published: May 13, 2011

Citation
Bernhard Baumann, Benjamin Potsaid, Martin F. Kraus, Jonathan J. Liu, David Huang, Joachim Hornegger, Alex E. Cable, Jay S. Duker, and James G. Fujimoto, "Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT," Biomed. Opt. Express 2, 1539-1552 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-6-1539


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