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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 6 — Jun. 1, 2011
  • pp: 1626–1636

Cramer-Rao analysis of steady-state and time-domain fluorescence diffuse optical imaging

M. Boffety, M. Allain, A. Sentenac, M. Massonneau, and R. Carminati  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 6, pp. 1626-1636 (2011)

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Using a Cramer-Rao analysis, we study the theoretical performances of a time and spatially resolved fDOT imaging system for jointly estimating the position and the concentration of a point-wide fluorescent volume in a diffusive sample. We show that the fluorescence lifetime is a critical parameter for the precision of the technique. A time resolved fDOT system that does not use spatial information is also considered. In certain cases, a simple steady-state configuration may be as efficient as this time resolved fDOT system.

© 2011 OSA

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration

ToC Category:
Diffuse Optical Imaging

Original Manuscript: January 21, 2011
Revised Manuscript: May 13, 2011
Manuscript Accepted: May 15, 2011
Published: May 19, 2011

M. Boffety, M. Allain, A. Sentenac, M. Massonneau, and R. Carminati, "Cramer-Rao analysis of steady-state and time-domain fluorescence diffuse optical imaging," Biomed. Opt. Express 2, 1626-1636 (2011)

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Fig. 1 Fig. 2 Fig. 3
Fig. 4 Fig. 5

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