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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 6 — Jun. 1, 2011
  • pp: 1664–1673

Optics InfoBase > Biomedical Optics Express > Volume 2 > Issue 6 > Page 1664

Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approach

Suneetha Devpura, Bensachee Pattamadilok, Zain U. Syed, Pranita Vemulapalli, Marsha Henderson, Steven J. Rehse, Iltefat Hamzavi, Henry W. Lim, and Ratna Naik  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 6, pp. 1664-1673 (2011)
http://dx.doi.org/10.1364/BOE.2.001664


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Abstract

Quantification of skin changes due to acanthosis nigricans (AN), a disorder common among insulin-resistant diabetic and obese individuals, was investigated using two optical techniques: diffuse reflectance spectroscopy (DRS) and colorimetry. Measurements were obtained from AN lesions on the neck and two control sites of eight AN patients. A principal component/discriminant function analysis successfully differentiated between AN lesion and normal skin with 87.7% sensitivity and 94.8% specificity in DRS measurements and 97.2% sensitivity and 96.4% specificity in colorimetry measurements.

© 2011 OSA

OCIS Codes
(170.1580) Medical optics and biotechnology : Chemometrics
(170.1610) Medical optics and biotechnology : Clinical applications
(170.1870) Medical optics and biotechnology : Dermatology
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Dermatological Applications

History
Original Manuscript: April 4, 2011
Revised Manuscript: May 18, 2011
Manuscript Accepted: May 19, 2011
Published: May 20, 2011

Citation
Suneetha Devpura, Bensachee Pattamadilok, Zain U. Syed, Pranita Vemulapalli, Marsha Henderson, Steven J. Rehse, Iltefat Hamzavi, Henry W. Lim, and Ratna Naik, "Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approach," Biomed. Opt. Express 2, 1664-1673 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-6-1664


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