OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 6 — Jun. 1, 2011
  • pp: 1664–1673

Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approach

Suneetha Devpura, Bensachee Pattamadilok, Zain U. Syed, Pranita Vemulapalli, Marsha Henderson, Steven J. Rehse, Iltefat Hamzavi, Henry W. Lim, and Ratna Naik  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 6, pp. 1664-1673 (2011)
http://dx.doi.org/10.1364/BOE.2.001664


View Full Text Article

Enhanced HTML    Acrobat PDF (1116 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Quantification of skin changes due to acanthosis nigricans (AN), a disorder common among insulin-resistant diabetic and obese individuals, was investigated using two optical techniques: diffuse reflectance spectroscopy (DRS) and colorimetry. Measurements were obtained from AN lesions on the neck and two control sites of eight AN patients. A principal component/discriminant function analysis successfully differentiated between AN lesion and normal skin with 87.7% sensitivity and 94.8% specificity in DRS measurements and 97.2% sensitivity and 96.4% specificity in colorimetry measurements.

© 2011 OSA

OCIS Codes
(170.1580) Medical optics and biotechnology : Chemometrics
(170.1610) Medical optics and biotechnology : Clinical applications
(170.1870) Medical optics and biotechnology : Dermatology
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Dermatological Applications

History
Original Manuscript: April 4, 2011
Revised Manuscript: May 18, 2011
Manuscript Accepted: May 19, 2011
Published: May 20, 2011

Citation
Suneetha Devpura, Bensachee Pattamadilok, Zain U. Syed, Pranita Vemulapalli, Marsha Henderson, Steven J. Rehse, Iltefat Hamzavi, Henry W. Lim, and Ratna Naik, "Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approach," Biomed. Opt. Express 2, 1664-1673 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-6-1664


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. K. M. Flegal, M. D. Carroll, C. L. Ogden, and L. R. Curtin, “Prevalence and trends in obesity among US adults, 1999-2008,” JAMA 303(3), 235–241 (2010). [CrossRef] [PubMed]
  2. A. S. Katz, D. C. Goff, and S. R. Feldman, “Acanthosis nigricans in obese patients: presentations and implications for prevention of atherosclerotic vascular disease,” Dermatol. Online J. 6(1), 1 (2000). [PubMed]
  3. G. Yosipovitch, A. DeVore, and A. Dawn, “Obesity and the skin: skin physiology and skin manifestations of obesity,” J. Am. Acad. Dermatol. 56(6), 901–916, quiz 917–920 (2007). [CrossRef] [PubMed]
  4. A. Ghatak, Optics, 2nd ed. (Tata McGraw-Hill, New Delhi, India, 2002).
  5. T. J. Farrell, M. S. Patterson, and B. Wilson, “A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo,” Med. Phys. 19(4), 879–888 (1992). [CrossRef] [PubMed]
  6. G. Zonios, L. T. Perelman, V. Backman, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M. S. Feld, “Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo,” Appl. Opt. 38(31), 6628–6637 (1999). [CrossRef] [PubMed]
  7. L. V. Wang and H.-I. Wu, Biomedical Optics: Principles and Imaging (Wiley-Interscience, 2007).
  8. G. Zonios, J. Bykowski, and N. Kollias, “Skin melanin, hemoglobin, and light scattering properties can be quantitatively assessed in vivo using diffuse reflectance spectroscopy,” J. Invest. Dermatol. 117(6), 1452–1457 (2001). [CrossRef] [PubMed]
  9. R. A. Schwarz, D. Arifler, S. K. Chang, I. Pavlova, I. A. Hussain, V. Mack, B. Knight, R. Richards-Kortum, and A. M. Gillenwater, “Ball lens coupled fiber-optic probe for depth-resolved spectroscopy of epithelial tissue,” Opt. Lett. 30(10), 1159–1161 (2005). [CrossRef] [PubMed]
  10. R. A. Schwarz, W. Gao, D. Daye, M. D. Williams, R. Richards-Kortum, and A. M. Gillenwater, “Autofluorescence and diffuse reflectance spectroscopy of oral epithelial tissue using a depth-sensitive fiber-optic probe,” Appl. Opt. 47(6), 825–834 (2008). [CrossRef] [PubMed]
  11. K. M. Katika and L. Pilon, “Steady-state directional diffuse reflectance and fluorescence of human skin,” Appl. Opt. 45(17), 4174–4183 (2006). [CrossRef] [PubMed]
  12. S. Prince and S. Malarvizhi, “Analysis of diffuse reflectance spectra of various skin conditions by principal component method,” in International Conference on Biomedical and Pharmaceutical Engineering (ICBPE, India. 2009), pp.1–4.
  13. Konica Minolta, “Precise color communication: color control from perception to instrumentation,” 1998, http://www.konicaminolta.com/sensingusa/products/Color-Measurement/spectrophotometer2/cm2600d-2500d/index.html .
  14. P. Clarys, K. Alewaeters, R. Lambrecht, and A. O. Barel, “Skin color measurements: comparison between three instruments: the Chromameter(R), the DermaSpectrometer(R) and the Mexameter(R),” Skin Res. Technol. 6(4), 230–238 (2000). [CrossRef] [PubMed]
  15. G. N. Stamatas, B. Z. Zmudzka, N. Kollias, and J. Z. Beer, “In vivo measurement of skin erythema and pigmentation: new means of implementation of diffuse reflectance spectroscopy with a commercial instrument,” Br. J. Dermatol. 159(3), 683–690 (2008). [CrossRef] [PubMed]
  16. L. Andreassi and L. Flori, “Practical applications of cutaneous colorimetry,” Clin. Dermatol. 13(4), 369–373 (1995). [CrossRef] [PubMed]
  17. B. Pattamadilok, S. Devpura, Z. U. Syed, P. Vemulapalli, M. Henderson, S. J. Rehse, B. H. Mahmoud, H. W. Lim, R. Naik, I. Hamzavi, are preparing a manuscript to be called “Quantitative skin color measurements: comparison between colorimetry and diffuse reflectance spectroscopy in acanthosis nigricans patients.”
  18. J. A. Delgado Atencio, E. E. Orozco Guillén, S. Vázquez y Montiel, M. Cunill Rodríguez, J. Castro Ramos, J. L. Gutiérrez, and F. Martínez, “Influence of probe pressure on human skin diffuse reflectance spectroscopy measurements,” Opt. Memory Neural Networks 18(1), 6–14 (2009). [CrossRef]
  19. W. R. Klecka, Discriminant Analysis, Series: Quantitative Applications in the Social Sciences (Sage Publication, Calif., USA, 1980).
  20. G. N. Stamatas, B. Z. Zmudzka, N. Kollias, and J. Z. Beer, “Non-invasive measurements of skin pigmentation in situ,” Pigment Cell Res. 17(6), 618–626 (2004). [CrossRef] [PubMed]
  21. S. J. Mason and N. E. Graham, “Areas beneath the relative operating characteristics (ROC) and relative operating levels (ROL) curves: Statistical significance and interpretation,” Q. J. R. Meteorol. Soc. 128(584), 2145–2166 (2002). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4 Fig. 5
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited