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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 6 — Jun. 1, 2011
  • pp: 1674–1686

Optics InfoBase > Biomedical Optics Express > Volume 2 > Issue 6 > Page 1674

Integrated adaptive optics optical coherence tomography and adaptive optics scanning laser ophthalmoscope system for simultaneous cellular resolution in vivo retinal imaging

Robert J. Zawadzki, Steven M. Jones, Suman Pilli, Sandra Balderas-Mata, Dae Yu Kim, Scot S. Olivier, and John S. Werner  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 6, pp. 1674-1686 (2011)
http://dx.doi.org/10.1364/BOE.2.001674


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Abstract

We describe an ultrahigh-resolution (UHR) retinal imaging system that combines adaptive optics Fourier-domain optical coherence tomography (AO-OCT) with an adaptive optics scanning laser ophthalmoscope (AO-SLO) to allow simultaneous data acquisition by the two modalities. The AO-SLO subsystem was integrated into the previously described AO-UHR OCT instrument with minimal changes to the latter. This was done in order to ensure optimal performance and image quality of the AO- UHR OCT. In this design both imaging modalities share most of the optical components including a common AO-subsystem and vertical scanner. One of the benefits of combining Fd-OCT with SLO includes automatic co-registration between two acquisition channels for direct comparison between retinal structures imaged by both modalities (e.g., photoreceptor mosaics or microvasculature maps). Because of differences in the detection scheme of the two systems, this dual imaging modality instrument can provide insight into retinal morphology and potentially function, that could not be accessed easily by a single system. In this paper we describe details of the components and parameters of the combined instrument, including incorporation of a novel membrane magnetic deformable mirror with increased stroke and actuator count used as a single wavefront corrector. We also discuss laser safety calculations for this multimodal system. Finally, retinal images acquired in vivo with this system are presented.

© 2011 OSA

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(110.4500) Imaging systems : Optical coherence tomography
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.0110) Medical optics and biotechnology : Imaging systems
(170.4470) Medical optics and biotechnology : Ophthalmology
(220.1000) Optical design and fabrication : Aberration compensation

ToC Category:
Ophthalmology Applications

History
Original Manuscript: March 28, 2011
Revised Manuscript: May 20, 2011
Manuscript Accepted: May 20, 2011
Published: May 24, 2011

Virtual Issues
Cellular Imaging of the Retina (2011) Biomedical Optics Express

Citation
Robert J. Zawadzki, Steven M. Jones, Suman Pilli, Sandra Balderas-Mata, Dae Yu Kim, Scot S. Olivier, and John S. Werner, "Integrated adaptive optics optical coherence tomography and adaptive optics scanning laser ophthalmoscope system for simultaneous cellular resolution in vivo retinal imaging," Biomed. Opt. Express 2, 1674-1686 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-6-1674


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