OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 6 — Jun. 1, 2011
  • pp: 1703–1716

Narrow-band pass filter array for integrated opto-electronic spectroscopy detectors to assess esophageal tissue

Débora S. Ferreira, Jelena Mirkovic, Reinoud F. Wolffenbuttel, José H. Correia, Michael S. Feld, and Graça Minas  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 6, pp. 1703-1716 (2011)

View Full Text Article

Enhanced HTML    Acrobat PDF (2938 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



A strategy for spectroscopy tissue diagnosis using a small number of wavelengths is reported. The feasibility to accurately quantify tissue information using only 16 wavelengths is demonstrated with several wavelength reduction simulations of the existing esophageal data set. These results are an important step for the development of a miniaturized, robust and low-cost spectroscopy system. This system is based on a sub-millimeter high-selective filter array that offers prospects for a simplified miniature spectrographic detector for a future diagnostic tool to improve the diagnosis of dysplasia. Several thin-film optical filters are optimized and fabricated and its spectral performance is shown to be sufficient for the selection of specific wavelength bands.

© 2011 OSA

OCIS Codes
(120.2230) Instrumentation, measurement, and metrology : Fabry-Perot
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(310.0310) Thin films : Thin films

ToC Category:
Spectroscopic Diagnostics

Original Manuscript: March 28, 2011
Revised Manuscript: May 21, 2011
Manuscript Accepted: May 23, 2011
Published: May 25, 2011

Débora S. Ferreira, Jelena Mirkovic, Reinoud F. Wolffenbuttel, José H. Correia, Michael S. Feld, and Graça Minas, "Narrow-band pass filter array for integrated opto-electronic spectroscopy detectors to assess esophageal tissue," Biomed. Opt. Express 2, 1703-1716 (2011)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. I. Georgakoudi, B. C. Jacobson, J. Van Dam, V. Backman, M. B. Wallace, M. G. Müller, Q. Zhang, K. Badizadegan, D. Sun, G. A. Thomas, L. T. Perelman, and M. S. Feld, “Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett’s esophagus,” Gastroenterology 120(7), 1620–1629 (2001). [CrossRef] [PubMed]
  2. J. W. Tunnell, A. E. Desjardins, L. Galindo, I. Georgakoudi, S. A. McGee, J. Mirkovic, M. G. Mueller, J. Nazemi, F. T. Nguyen, A. Wax, Q. G. Zhang, R. R. Dasari, and M. S. Feld, “Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia,” Technol. Cancer Res. Treat. 2(6), 505–514 (2003). [PubMed]
  3. J. F. Fléjou, “Barrett’s oesophagus: from metaplasia to dysplasia and cancer,” Gut 54(Suppl 1), i6–i12 (2005). [CrossRef] [PubMed]
  4. S. Villette, S. Pigaglio-Deshayes, C. Vever-Bizet, P. Validire, and G. Bourg-Heckly, “Ultraviolet-induced autofluorescence characterization of normal and tumoral esophageal epithelium cells with quantitation of NAD(P)H,” Photochem. Photobiol. Sci. 5(5), 483–492 (2006). [CrossRef] [PubMed]
  5. A. J. Cameron, “Management of Barrett’s esophagus,” Mayo Clin. Proc. 73(5), 457–461 (1998). [CrossRef] [PubMed]
  6. B. J. Reid, R. C. Haggitt, C. E. Rubin, G. Roth, C. M. Surawicz, G. Van Belle, K. Lewin, W. M. Weinstein, D. A. Antonioli, H. Goldman, W. Macdonald, and D. Owen, “Observer variation in the diagnosis of dysplasia in Barrett’s esophagus,” Hum. Pathol. 19(2), 166–178 (1988). [CrossRef] [PubMed]
  7. R. E. Petras, M. V. Sivak, and T. W. Rice, “Barrett’s esophagus. a review of the pathologist’s role in diagnosis and management,” Pathol. Annu. 26(Pt 2), 1–32 (1991). [PubMed]
  8. K. K. Wang, M. Wongkeesong, N. S. Buttar, and American Gastroenterological Association, “American Gastroenterological Association medical position statement: Role of the gastroenterologist in the management of esophageal carcinoma,” Gastroenterology 128(5), 1468–1470 (2005). [CrossRef] [PubMed]
  9. L. M. Wong Kee Song, “Optical spectroscopy for the detection of dysplasia in Barrett’s esophagus,” Clin. Gastroenterol. Hepatol. 3(7Suppl 1), S2–S7 (2005). [CrossRef] [PubMed]
  10. C. C. Yu, C. Lau, G. O’Donoghue, J. Mirkovic, S. McGee, L. Galindo, A. Elackattu, E. Stier, G. Grillone, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Quantitative spectroscopic imaging for non-invasive early cancer detection,” Opt. Express 16(20), 16227–16239 (2008). [CrossRef] [PubMed]
  11. M. Panjehpour, B. F. Overholt, T. Vo-Dinh, R. C. Haggitt, D. H. Edwards, and F. P. Buckley, “Endoscopic fluorescence detection of high-grade dysplasia in Barrett’s esophagus,” Gastroenterology 111(1), 93–101 (1996). [CrossRef] [PubMed]
  12. T. Vo-Dinh, M. Panjehpour, and B. F. Overholt, “Laser-induced fluorescence for esophageal cancer and dysplasia diagnosis,” Ann. N. Y. Acad. Sci. 838(Advances in Optical Biopsy and Optical Mammography), 116–122 (1998). [CrossRef] [PubMed]
  13. T. J. Pfefer, D. Y. Paithankar, J. M. Poneros, K. T. Schomacker, and N. S. Nishioka, “Temporally and spectrally resolved fluorescence spectroscopy for the detection of high grade dysplasia in Barrett’s esophagus,” Lasers Surg. Med. 32(1), 10–16 (2003). [CrossRef] [PubMed]
  14. M. A. Ortner, B. Ebert, E. Hein, K. Zumbusch, D. Nolte, U. Sukowski, J. Weber-Eibel, B. Fleige, M. Dietel, M. Stolte, G. Oberhuber, R. Porschen, B. Klump, H. Hörtnagl, H. Lochs, and H. Rinneberg, “Time gated fluorescence spectroscopy in Barrett’s oesophagus,” Gut 52(1), 28–33 (2003). [CrossRef] [PubMed]
  15. G. Zonios, L. T. Perelman, V. M. Backman, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M. S. Feld, “Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo,” Appl. Opt. 38(31), 6628–6637 (1999). [CrossRef] [PubMed]
  16. M. G. Müller, I. Georgakoudi, Q. G. Zhang, J. Wu, and M. S. Feld, “Intrinsic fluorescence spectroscopy in turbid media: disentangling effects of scattering and absorption,” Appl. Opt. 40(25), 4633–4646 (2001). [CrossRef] [PubMed]
  17. B. Yu, J. Y. Lo, T. F. Kuech, G. M. Palmer, J. E. Bender, and N. Ramanujam, “Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo,” J. Biomed. Opt. 13(6), 060505 (2008). [CrossRef] [PubMed]
  18. J. Y. Lo, B. Yu, H. L. Fu, J. E. Bender, G. M. Palmer, T. F. Kuech, and N. Ramanujam, “A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes,” Opt. Express 17(3), 1372–1384 (2009). [CrossRef] [PubMed]
  19. J. Mirkovic, C. Lau, S. McGee, C. C. Yu, J. Nazemi, L. Galindo, V. Feng, T. Darragh, A. de Las Morenas, C. Crum, E. Stier, M. S. Feld, and K. Badizadegan, “Effect of anatomy on spectroscopic detection of cervical dysplasia,” J. Biomed. Opt. 14(4), 044021 (2009). [CrossRef] [PubMed]
  20. Y. Narukawa, M. Ichikawa, D. Sanga, M. Sano, and T. Mukai, “White light emitting diodes with super-high luminous efficacy,” J. Phys. D Appl. Phys. 43(35), 354002 (2010). [CrossRef]
  21. L. Phee, D. Accoto, A. Menciassi, C. Stefanini, M. C. Carrozza, and P. Dario, “Analysis and development of locomotion devices for the gastrointestinal tract,” IEEE Trans. Biomed. Eng. 49(6), 613–616 (2002). [CrossRef] [PubMed]
  22. A. Menciassi, A. Moglia, S. Gorini, G. Pernorio, C. Stefanini, and P. Dario, “Shape memory alloy clamping devices of a capsule for monitoring tasks in the gastrointestinal tract,” J. Micromech. Microeng. 15(11), 2045–2055 (2005). [CrossRef]
  23. M. Quirini, S. Scapellato, P. Valdastri, A. Menciassi, and P. Dario, “An approach to capsular endoscopy with active motion,” in Proceedings of the 29th Annual International Conference of the IEEE EMBS (Institute of Electrical and Electronics Engineers, New York, 2007), pp. 2827–2830.
  24. J. G. Rocha, G. Minas, and S. Lanceros-Mendez, “Pixel Readout Circuit for X-Ray Imagers,” IEEE Sens. J. 10(11), 1740–1745 (2010). [CrossRef]
  25. H. A. Macleod, Thin-Film Optical Filters (E.D. Institute of Physics Publishing, 2001).
  26. G. Minas, R. F. Wolffenbuttel, and J. H. Correia, “A lab-on-a-chip for spectrophotometric analysis of biological fluids,” Lab Chip 5(11), 1303–1309 (2005). [CrossRef] [PubMed]
  27. G. Minas, R. F. Wolffenbuttel, and J. H. Correia, “An array of highly selective Fabry-Perot optical channels for biological fluid analysis by optical absorption using a white light source for illumination,” J. Opt. A, Pure Appl. Opt. 8(3), 272–278 (2006). [CrossRef]
  28. G. Minas, J. C. Ribeiro, R. F. Wolffenbuttel, and J. H. Correia, “On-Chip integrated CMOS optical detection microsystem for spectrophotometric analyses in biological microfluidic systems,” in Proceedings IEEE Int. Symposium on Industrial Electronics (Institute of Electrical and Electronics Engineers, New York, 2005), pp. 1133–1138.

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited