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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 7 — Jul. 1, 2011
  • pp: 1828–1835

Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods

Carolyn L. Bayer, Yun-Sheng Chen, Seungsoo Kim, Srivalleesha Mallidi, Konstantin Sokolov, and Stanislav Emelianov  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 7, pp. 1828-1835 (2011)

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The establishment of multiplex photoacoustic molecular imaging to characterize heterogeneous tissues requires the use of a tunable, thermally stable contrast agent targeted to specific cell types. We have developed a multiplex photoacoustic imaging technique which uses targeted silica-coated gold nanorods to distinguish cell inclusions in vitro. This paper describes the use of tunable targeted silica-coated gold nanorods (SiO2-AuNRs) as contrast agents for photoacoustic molecular imaging. SiO2-AuNRs with peak absorption wavelengths of 780 nm and 830 nm were targeted to cells expressing different cell receptors. Cells were incubated with the targeted SiO2-AuNRs, incorporated in a tissue phantom, and imaged using multiwavelength photoacoustic imaging. We used photoacoustic imaging and statistical correlation analysis to distinguish between the unique cell inclusions within the tissue phantom.

© 2011 OSA

OCIS Codes
(160.1050) Materials : Acousto-optical materials
(170.0110) Medical optics and biotechnology : Imaging systems
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(160.4236) Materials : Nanomaterials
(110.5125) Imaging systems : Photoacoustics
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Photoacoustic Imaging and Spectroscopy

Original Manuscript: April 18, 2011
Revised Manuscript: May 27, 2011
Manuscript Accepted: May 31, 2011
Published: June 2, 2011

Carolyn L. Bayer, Yun-Sheng Chen, Seungsoo Kim, Srivalleesha Mallidi, Konstantin Sokolov, and Stanislav Emelianov, "Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods," Biomed. Opt. Express 2, 1828-1835 (2011)

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