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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 7 — Jul. 1, 2011
  • pp: 1931–1945

High-speed camera with real time processing for frequency domain imaging

Victor Shia, David Watt, and Gregory W. Faris  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 7, pp. 1931-1945 (2011)

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We describe a high-speed camera system for frequency domain imaging suitable for applications such as in vivo diffuse optical imaging and fluorescence lifetime imaging. 14-bit images are acquired at 2 gigapixels per second and analyzed with real-time pipeline processing using field programmable gate arrays (FPGAs). Performance of the camera system has been tested both for RF-modulated laser imaging in combination with a gain-modulated image intensifier and a simpler system based upon an LED light source. System amplitude and phase noise are measured and compared against theoretical expressions in the shot noise limit presented for different frequency domain configurations. We show the camera itself is capable of shot noise limited performance for amplitude and phase in as little as 3 ms, and when used in combination with the intensifier the noise levels are nearly shot noise limited. The best phase noise in a single pixel is 0.04 degrees for a 1 s integration time.

© 2011 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3650) Medical optics and biotechnology : Lifetime-based sensing
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Image Processing

Original Manuscript: May 2, 2011
Revised Manuscript: June 13, 2011
Manuscript Accepted: June 13, 2011
Published: June 15, 2011

Victor Shia, David Watt, and Gregory W. Faris, "High-speed camera with real time processing for frequency domain imaging," Biomed. Opt. Express 2, 1931-1945 (2011)

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