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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 7 — Jul. 1, 2011
  • pp: 1969–1985

Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements

Daniel Irwin, Lixin Dong, Yu Shang, Ran Cheng, Mahesh Kudrimoti, Scott D. Stevens, and Guoqiang Yu  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 7, pp. 1969-1985 (2011)
http://dx.doi.org/10.1364/BOE.2.001969


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Abstract

In this study we evaluate the influences of optical property assumptions on near-infrared diffuse correlation spectroscopy (DCS) flow index measurements. The optical properties, absorption coefficient (µa) and reduced scattering coefficient (µs′), are independently varied using liquid phantoms and measured concurrently with the flow index using a hybrid optical system combining a dual-wavelength DCS flow device with a commercial frequency-domain tissue-oximeter. DCS flow indices are calculated at two wavelengths (785 and 830 nm) using measured µa and µs′ or assumed constant µa and µs′. Inaccurate µs′ assumptions resulted in much greater flow index errors than inaccurate µa. Underestimated/overestimated µs′ from −35%/+175% lead to flow index errors of +110%/−80%, whereas underestimated/overestimated µa from −40%/+150% lead to −20%/+40%, regardless of the wavelengths used. Examination of a clinical study involving human head and neck tumors indicates up to +280% flow index errors resulted from inter-patient optical property variations. These findings suggest that studies involving significant µa and µs′ changes should concurrently measure flow index and optical properties for accurate extraction of blood flow information.

© 2011 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Noninvasive Optical Diagnostics

History
Original Manuscript: May 2, 2011
Revised Manuscript: June 13, 2011
Manuscript Accepted: June 14, 2011
Published: June 17, 2011

Citation
Daniel Irwin, Lixin Dong, Yu Shang, Ran Cheng, Mahesh Kudrimoti, Scott D. Stevens, and Guoqiang Yu, "Influences of tissue absorption and scattering on diffuse correlation spectroscopy blood flow measurements," Biomed. Opt. Express 2, 1969-1985 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-7-1969


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