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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 7 — Jul. 1, 2011
  • pp: 1986–2004

Woofer-tweeter adaptive optics scanning laser ophthalmoscopic imaging based on Lagrange-multiplier damped least-squares algorithm

Weiyao Zou, Xiaofeng Qi, and Stephen A. Burns  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 7, pp. 1986-2004 (2011)
http://dx.doi.org/10.1364/BOE.2.001986


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Abstract

We implemented a Lagrange-multiplier (LM)-based damped least-squares (DLS) control algorithm in a woofer-tweeter dual deformable-mirror (DM) adaptive optics scanning laser ophthalmoscope (AOSLO). The algorithm uses data from a single Shack-Hartmann wavefront sensor to simultaneously correct large-amplitude low-order aberrations by a woofer DM and small-amplitude higher-order aberrations by a tweeter DM. We measured the in vivo performance of high resolution retinal imaging with the dual DM AOSLO. We compared the simultaneous LM-based DLS dual DM controller with both single DM controller, and a successive dual DM controller. We evaluated performance using both wavefront (RMS) and image quality metrics including brightness and power spectrum. The simultaneous LM-based dual DM AO can consistently provide near diffraction-limited in vivo routine imaging of human retina.

© 2011 OSA

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(170.1790) Medical optics and biotechnology : Confocal microscopy
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices
(220.1080) Optical design and fabrication : Active or adaptive optics

ToC Category:
Ophthalmology Applications

History
Original Manuscript: April 14, 2011
Revised Manuscript: June 7, 2011
Manuscript Accepted: June 10, 2011
Published: June 17, 2011

Citation
Weiyao Zou, Xiaofeng Qi, and Stephen A. Burns, "Woofer-tweeter adaptive optics scanning laser ophthalmoscopic imaging based on Lagrange-multiplier damped least-squares algorithm," Biomed. Opt. Express 2, 1986-2004 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-7-1986


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