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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 7 — Jul. 1, 2011
  • pp: 2047–2054

Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels

Stefan A. Carp, Nadàege Roche-Labarbe, Maria-Angela Franceschini, Vivek J. Srinivasan, Sava Sakadžić, and David A. Boas  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 7, pp. 2047-2054 (2011)

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We suggest that Diffuse Correlation Spectroscopy (DCS) measurements of tissue blood flow primarily probe relative red blood cell (RBC) motion, due to the occurrence of multiple sequential scattering events within blood vessels. The magnitude of RBC shear-induced diffusion is known to correlate with flow velocity, explaining previous reports of linear scaling of the DCS “blood flow index” with tissue perfusion despite the observed diffusion-like auto-correlation decay. Further, by modeling RBC mean square displacement using a formulation that captures the transition from ballistic to diffusive motion, we improve the fit to experimental data and recover effective diffusion coefficients and velocity de-correlation time scales in the range expected from previous blood rheology studies.

© 2011 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Noninvasive Optical Diagnostics

Original Manuscript: April 4, 2011
Revised Manuscript: June 13, 2011
Manuscript Accepted: June 17, 2011
Published: June 24, 2011

Stefan A. Carp, Nadàege Roche-Labarbe, Maria-Angela Franceschini, Vivek J. Srinivasan, Sava Sakadžić, and David A. Boas, "Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels," Biomed. Opt. Express 2, 2047-2054 (2011)

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