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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 7 — Jul. 1, 2011
  • pp: 2055–2067

Performance of full-pupil line-scanning reflectance confocal microscopy in human skin and oral mucosa in vivo

Bjorg Larson, Sanjeewa Abeytunge, and Milind Rajadhyaksha  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 7, pp. 2055-2067 (2011)
http://dx.doi.org/10.1364/BOE.2.002055


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Abstract

Point-scanning reflectance confocal microscopes continue to be successfully translated for detection of skin cancer. Line-scanning, with the use of a single scanner and a linear-array detector, offers a potentially smaller, simpler and lower cost alternative approach, to accelerate widespread dissemination into the clinic. However, translation will require an understanding of imaging performance deep within scattering and aberrating human tissues. We report the results of an investigation of the performance of a full-pupil line-scanning reflectance confocal microscope in human skin and oral mucosa, in terms of resolution, optical sectioning, contrast, signal-to-noise ratio, imaging and the effect of speckle noise.

© 2011 OSA

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.1790) Medical optics and biotechnology : Confocal microscopy
(180.1790) Microscopy : Confocal microscopy
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Microscopy

History
Original Manuscript: May 2, 2011
Revised Manuscript: June 14, 2011
Manuscript Accepted: June 21, 2011
Published: June 27, 2011

Virtual Issues
Advances in Optics for Biotechnology, Medicine, and Surgery (2011) Biomedical Optics Express

Citation
Bjorg Larson, Sanjeewa Abeytunge, and Milind Rajadhyaksha, "Performance of full-pupil line-scanning reflectance confocal microscopy in human skin and oral mucosa in vivo," Biomed. Opt. Express 2, 2055-2067 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-7-2055


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