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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 7 — Jul. 1, 2011
  • pp: 2068–2081

Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements

Mamadou Diop, Kyle Verdecchia, Ting-Yim Lee, and Keith St Lawrence  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 7, pp. 2068-2081 (2011)
http://dx.doi.org/10.1364/BOE.2.002068


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Abstract

A primary focus of neurointensive care is the prevention of secondary brain injury, mainly caused by ischemia. A noninvasive bedside technique for continuous monitoring of cerebral blood flow (CBF) could improve patient management by detecting ischemia before brain injury occurs. A promising technique for this purpose is diffuse correlation spectroscopy (DCS) since it can continuously monitor relative perfusion changes in deep tissue. In this study, DCS was combined with a time-resolved near-infrared technique (TR-NIR) that can directly measure CBF using indocyanine green as a flow tracer. With this combination, the TR-NIR technique can be used to convert DCS data into absolute CBF measurements. The agreement between the two techniques was assessed by concurrent measurements of CBF changes in piglets. A strong correlation between CBF changes measured by TR-NIR and changes in the scaled diffusion coefficient measured by DCS was observed (R2 = 0.93) with a slope of 1.05 ± 0.06 and an intercept of 6.4 ± 4.3% (mean ± standard error).

© 2011 OSA

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Noninvasive Optical Diagnostics

History
Original Manuscript: May 19, 2011
Revised Manuscript: June 23, 2011
Manuscript Accepted: June 25, 2011
Published: June 28, 2011

Citation
Mamadou Diop, Kyle Verdecchia, Ting-Yim Lee, and Keith St Lawrence, "Calibration of diffuse correlation spectroscopy with a time-resolved near-infrared technique to yield absolute cerebral blood flow measurements," Biomed. Opt. Express 2, 2068-2081 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-7-2068


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