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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 8 — Aug. 1, 2011
  • pp: 2175–2188

Optics InfoBase > Biomedical Optics Express > Volume 2 > Issue 8 > Page 2175

Doppler velocity detection limitations in spectrometer-based versus swept-source optical coherence tomography

Hansford C. Hendargo, Ryan P. McNabb, Al-Hafeez Dhalla, Neal Shepherd, and Joseph A. Izatt  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 8, pp. 2175-2188 (2011)
http://dx.doi.org/10.1364/BOE.2.002175


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Abstract

Recent advances in Doppler techniques have enabled high sensitivity imaging of biological flow to measure blood velocities and vascular perfusion. Here we compare spectrometer-based and wavelength-swept Doppler OCT implementations theoretically and experimentally, characterizing the lower and upper observable velocity limits in each configuration. We specifically characterize the washout limit for Doppler OCT, the velocity at which signal degradation results in loss of flow information, which is valid for both quantitative and qualitative flow imaging techniques. We also clearly differentiate the washout effect from the separate phenomenon of phase wrapping. We demonstrate that the maximum detectable Doppler velocity is determined by the fringe washout limit and not phase wrapping. Both theory and experimental results from phantom flow data and retinal blood flow data demonstrate the superiority of the swept-source technique for imaging vessels with high flow rates.

© 2011 OSA

OCIS Codes
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: May 25, 2011
Revised Manuscript: July 1, 2011
Manuscript Accepted: July 1, 2011
Published: July 6, 2011

Citation
Hansford C. Hendargo, Ryan P. McNabb, Al-Hafeez Dhalla, Neal Shepherd, and Joseph A. Izatt, "Doppler velocity detection limitations in spectrometer-based versus swept-source optical coherence tomography," Biomed. Opt. Express 2, 2175-2188 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-8-2175


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References

  1. Z. Chen, T. E. Milner, D. Dave, and J. S. Nelson, “Optical Doppler tomographic imaging of fluid flow velocity in highly scattering media,” Opt. Lett. 22(1), 64–66 (1997). [CrossRef] [PubMed]
  2. J. A. Izatt, M. D. Kulkarni, S. Yazdanfar, J. K. Barton, and A. J. Welch, “In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography,” Opt. Lett. 22(18), 1439–1441 (1997). [CrossRef] [PubMed]
  3. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express 11(8), 889–894 (2003). [CrossRef] [PubMed]
  4. M. A. Choma, M. V. Sarunic, C. Yang, and J. A. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express 11(18), 2183–2189 (2003). [CrossRef] [PubMed]
  5. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett. 28(21), 2067–2069 (2003). [CrossRef] [PubMed]
  6. R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, “Three dimensional optical angiography,” Opt. Express 15(7), 4083–4097 (2007). [CrossRef] [PubMed]
  7. Y. K. Tao, A. M. Davis, and J. A. Izatt, “Single-pass volumetric bidirectional blood flow imaging spectral domain optical coherence tomography using a modified Hilbert transform,” Opt. Express 16(16), 12350–12361 (2008). [CrossRef] [PubMed]
  8. M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, A. Kowalczyk, and M. Wojtkowski, “Flow velocity estimation using joint Spectral and Time domain Optical Coherence Tomography,” Opt. Express 16(9), 6008–6025 (2008). [CrossRef] [PubMed]
  9. Y. K. Tao, K. M. Kennedy, and J. A. Izatt, “Velocity-resolved 3D retinal microvessel imaging using single-pass flow imaging spectral domain optical coherence tomography,” Opt. Express 17(5), 4177–4188 (2009). [CrossRef] [PubMed]
  10. R. K. Wang and L. An, “Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo,” Opt. Express 17(11), 8926–8940 (2009). [CrossRef] [PubMed]
  11. I. Grulkowski, I. Gorczynska, M. Szkulmowski, D. Szlag, A. Szkulmowska, R. A. Leitgeb, A. Kowalczyk, and M. Wojtkowski, “Scanning protocols dedicated to smart velocity ranging in spectral OCT,” Opt. Express 17(26), 23736–23754 (2009). [CrossRef] [PubMed]
  12. Y. Yasuno, S. Makita, T. Endo, G. Aoki, M. Itoh, and T. Yatagai, “Simultaneous B-M-mode scanning method for real-time full-range Fourier domain optical coherence tomography,” Appl. Opt. 45(8), 1861–1865 (2006). [CrossRef] [PubMed]
  13. A. H. Bachmann, M. L. Villiger, C. Blatter, T. Lasser, and R. A. Leitgeb, “Resonant Doppler flow imaging and optical vivisection of retinal blood vessels,” Opt. Express 15(2), 408–422 (2007). [CrossRef] [PubMed]
  14. F. Jaillon, S. Makita, M. Yabusaki, and Y. Yasuno, “Parabolic BM-scan technique for full range Doppler spectral domain optical coherence tomography,” Opt. Express 18(2), 1358–1372 (2010). [CrossRef] [PubMed]
  15. A. Mariampillai, B. A. Standish, E. H. Moriyama, M. Khurana, N. R. Munce, M. K. K. Leung, J. Jiang, A. Cable, B. C. Wilson, I. A. Vitkin, and V. X. D. Yang, “Speckle variance detection of microvasculature using swept-source optical coherence tomography,” Opt. Lett. 33(13), 1530–1532 (2008). [CrossRef] [PubMed]
  16. J. Fingler, D. Schwartz, C. Yang, and S. E. Fraser, “Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography,” Opt. Express 15(20), 12636–12653 (2007). [CrossRef] [PubMed]
  17. J. Fingler, R. J. Zawadzki, J. S. Werner, D. Schwartz, and S. E. Fraser, “Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique,” Opt. Express 17(24), 22190–22200 (2009). [CrossRef] [PubMed]
  18. L. Yu and Z. Chen, “Doppler variance imaging for three-dimensional retina and choroid angiography,” J. Biomed. Opt. 15(1), 016029 (2010). [CrossRef] [PubMed]
  19. S. Zotter, M. Pircher, T. Torzicky, M. Bonesi, E. Götzinger, R. A. Leitgeb, and C. K. Hitzenberger, “Visualization of microvasculature by dual-beam phase-resolved Doppler optical coherence tomography,” Opt. Express 19(2), 1217–1227 (2011). [CrossRef] [PubMed]
  20. S. Makita, F. Jaillon, M. Yamanari, M. Miura, and Y. Yasuno, “Comprehensive in vivo micro-vascular imaging of the human eye by dual-beam-scan Doppler optical coherence angiography,” Opt. Express 19(2), 1271–1283 (2011). [CrossRef] [PubMed]
  21. M. A. Choma, A. K. Ellerbee, S. Yazdanfar, and J. A. Izatt, “Doppler flow imaging of cytoplasmic streaming using spectral domain phase microscopy,” J. Biomed. Opt. 11(2), 024014 (2006). [CrossRef] [PubMed]
  22. Y. Wang, B. A. Bower, J. A. Izatt, O. Tan, and D. Huang, “In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography,” J. Biomed. Opt. 12(4), 041215 (2007). [CrossRef] [PubMed]
  23. Y. Wang, B. A. Bower, J. A. Izatt, O. Tan, and D. Huang, “Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography,” J. Biomed. Opt. 13(6), 064003 (2008). [CrossRef] [PubMed]
  24. B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011). [CrossRef] [PubMed]
  25. Y. Wang, A. Fawzi, O. Tan, J. Gil-Flamer, and D. Huang, “Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography,” Opt. Express 17(5), 4061–4073 (2009). [CrossRef] [PubMed]
  26. C. E. Riva, J. E. Grunwald, S. H. Sinclair, and B. L. Petrig, “Blood velocity and volumetric flow rate in human retinal vessels,” Invest. Ophthalmol. Vis. Sci. 26(8), 1124–1132 (1985). [PubMed]
  27. J. Walther, G. Mueller, H. Morawietz, and E. Koch, “Signal power decrease due to fringe washout as an extension of the limited Doppler flow measurement range in spectral domain optical coherence tomography,” J. Biomed. Opt. 15(4), 041511 (2010). [CrossRef] [PubMed]
  28. S. H. Yun, G. J. Tearney, J. de Boer, and B. E. Bouma, “Motion artifacts in optical coherence tomography with frequency-domain ranging,” Opt. Express 12(13), 2977–2998 (2004). [CrossRef] [PubMed]
  29. J. A. Izatt and M. A. Choma, “Theory of optical coherence tomography,” in Optical Coherence Tomography: Technology and Applications, W. Drexler, and J. G. Fujimoto, eds. (Springer, 2008), pp. 47-72.
  30. M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Phase contrast coherence microscopy based on transverse scanning,” Opt. Lett. 34(12), 1750–1752 (2009). [CrossRef] [PubMed]
  31. B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Statistical properties of phase-decorrelation in phase-resolved Doppler optical coherence tomography,” IEEE Trans. Med. Imaging 28(6), 814–821 (2009). [CrossRef] [PubMed]
  32. S. Yazdanfar, C. Yang, M. V. Sarunic, and J. A. Izatt, “Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound,” Opt. Express 13(2), 410–416 (2005). [CrossRef] [PubMed]
  33. B. H. Park, M. C. Pierce, B. Cense, S.-H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. de Boer, “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 microm,” Opt. Express 13(11), 3931–3944 (2005). [CrossRef] [PubMed]
  34. B. J. Vakoc, S. H. Yun, J. de Boer, G. J. Tearney, and B. E. Bouma, “Phase-resolved optical frequency domain imaging,” Opt. Express 13(14), 5483–5493 (2005). [CrossRef] [PubMed]
  35. M. A. Choma, A. K. Ellerbee, C. Yang, T. L. Creazzo, and J. A. Izatt, “Spectral-domain phase microscopy,” Opt. Lett. 30(10), 1162–1164 (2005). [CrossRef] [PubMed]
  36. B. A. Bower, M. Zhao, R. J. Zawadzki, and J. A. Izatt, “Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation,” J. Biomed. Opt. 12(4), 041214 (2007). [CrossRef] [PubMed]
  37. B. R. White, M. C. Pierce, N. Nassif, B. Cense, B. H. Park, G. J. Tearney, B. E. Bouma, T. C. Chen, and J. de Boer, “In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography,” Opt. Express 11(25), 3490–3497 (2003). [CrossRef] [PubMed]
  38. R. A. Leitgeb, L. Schmetterer, W. Drexler, A. F. Fercher, R. J. Zawadzki, and T. Bajraszewski, “Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography,” Opt. Express 11(23), 3116–3121 (2003). [CrossRef] [PubMed]
  39. C. Joo, T. Akkin, B. Cense, B. H. Park, and J. F. de Boer, “Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging,” Opt. Lett. 30(16), 2131–2133 (2005). [CrossRef] [PubMed]
  40. H. C. Hendargo, M. Zhao, N. Shepherd, and J. A. Izatt, “Synthetic wavelength based phase unwrapping in spectral domain optical coherence tomography,” Opt. Express 17(7), 5039–5051 (2009). [CrossRef] [PubMed]
  41. S. H. Yun, G. J. Tearney, J. de Boer, and B. E. Bouma, “Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts,” Opt. Express 12(23), 5614–5624 (2004). [CrossRef] [PubMed]
  42. L. Wang, Y. Wang, S. Guo, J. Zhang, M. Bachman, G. P. Li, and Z. Chen, “Frequency domain phase-resolved optical Doppler and Doppler variance tomography,” Opt. Commun. 242(4-6), 345–350 (2004). [CrossRef]
  43. S. Makita, Y. Hong, M. Yamanari, T. Yatagai, and Y. Yasuno, “Optical coherence angiography,” Opt. Express 14(17), 7821–7840 (2006). [CrossRef] [PubMed]
  44. D. C. Ghiglia and M. D. Pritt, Two-Dimensional Phase Unwrapping: Theory, Algorithms, and Software (Wiley-Interscience, New York, 1998).
  45. S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. van Gemert, “Optical properties of Intralipid: a phantom medium for light propagation studies,” Lasers Surg. Med. 12(5), 510–519 (1992). [CrossRef] [PubMed]
  46. J. A. Curcio and C. C. Petty, “The Near Infrared Absorption Spectrum of Liquid Water,” J. Opt. Soc. Am. 41(5), 302–304 (1951). [CrossRef]
  47. A. Roggan, M. Friebel, K. Dörschel, A. Hahn, and G. Müller, “Optical Properties of Circulating Human Blood in the Wavelength Range 400-2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999). [CrossRef]
  48. P. H. M. Bovendeerd, A. A. Steenhoven, F. N. Vosse, and G. Vossers, “Steady entry flow in a curved pipe,” J. Fluid Mech. 177(-1), 233–246 (1987). [CrossRef]
  49. G. T. Feke, H. Tagawa, D. M. Deupree, D. G. Goger, J. Sebag, and J. J. Weiter, “Blood flow in the normal human retina,” Invest. Ophthalmol. Vis. Sci. 30(1), 58–65 (1989). [PubMed]

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