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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 8 — Aug. 1, 2011
  • pp: 2329–2338

Evaluation of optical clearing with the combined liquid paraffin and glycerol mixture

Jingyi Wang, Yanmei Liang, Shu Zhang, Yueqiao Zhou, Haiyang Ni, and Yan Li  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 8, pp. 2329-2338 (2011)

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By scanning biological tissues in vivo and in vitro with optical coherence tomography, it is found that liquid paraffin can enhance the percutaneous penetration of glycerol in deep layers of tissue and take synergistically optical clearing effect with glycerol. It is shown from experimental results that 30% - 50% liquid paraffin glycerol solutions have the best enhancement effect. Considering the refractive index of liquid paraffin and its medicinal value, we think liquid paraffin will play an important role in optical clearing as the penetration enhancer of glycerol in future clinical research.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6930) Medical optics and biotechnology : Tissue
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Optics of Tissue and Turbid Media

Original Manuscript: May 11, 2011
Revised Manuscript: June 2, 2011
Manuscript Accepted: July 17, 2011
Published: July 21, 2011

Jingyi Wang, Yanmei Liang, Shu Zhang, Yueqiao Zhou, Haiyang Ni, and Yan Li, "Evaluation of optical clearing with the combined liquid paraffin and glycerol mixture," Biomed. Opt. Express 2, 2329-2338 (2011)

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