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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 8 — Aug. 1, 2011
  • pp: 2339–2347

Terahertz reflectometry of burn wounds in a rat model

M. Hassan Arbab, Trevor C. Dickey, Dale P. Winebrenner, Antao Chen, Mathew B. Klein, and Pierre D. Mourad  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 8, pp. 2339-2347 (2011)
http://dx.doi.org/10.1364/BOE.2.002339


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Abstract

We present sub-millimeter wave reflectometry of an experimental rat skin burn model obtained by the Terahertz Time-Domain Spectroscopy (THz-TDS) technique. Full thickness burns, as confirmed by histology, were created on rats (n = 4) euthanized immediately prior to the experiments. Statistical analysis shows that the burned tissue exhibits higher reflectivity compared to normal skin over a frequency range between 0.5 and 0.7 THz (p < 0.05), likely due to post-burn formation of interstitial edema. Furthermore, we demonstrate that a double Debye dielectric relaxation model can be used to explain the terahertz response of both normal and less severely burned rat skin. Finally, our data suggest that the degree of conformation between the experimental burn measurements and the model for normal skin can potentially be used to infer the extent of burn severity.

© 2011 OSA

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6495) Spectroscopy : Spectroscopy, teraherz
(170.6795) Medical optics and biotechnology : Terahertz imaging

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: May 19, 2011
Revised Manuscript: July 13, 2011
Manuscript Accepted: July 15, 2011
Published: July 21, 2011

Citation
M. Hassan Arbab, Trevor C. Dickey, Dale P. Winebrenner, Antao Chen, Mathew B. Klein, and Pierre D. Mourad, "Terahertz reflectometry of burn wounds in a rat model," Biomed. Opt. Express 2, 2339-2347 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-8-2339


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