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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 8 — Aug. 1, 2011
  • pp: 2392–2402

Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography

Yiheng Lim, Masahiro Yamanari, Shinichi Fukuda, Yuichi Kaji, Takahiro Kiuchi, Masahiro Miura, Tetsuro Oshika, and Yoshiaki Yasuno  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 8, pp. 2392-2402 (2011)
http://dx.doi.org/10.1364/BOE.2.002392


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Abstract

We present a case series of cornea and anterior segment disorders investigated by an office-based polarization-sensitive optical coherence tomography (PS-OCT). Blebs of glaucoma patients treated by trabeculectomy, and corneas of keratoconus and keratoplasty patients were measured by PS-OCT. Birefringence formations in trabeculectomy bleb were measured in 1 control eye and 3 eyes of trabeculectomy model rabbits. Polarization insensitive scattering OCT and the depth-resolved birefringence were measured simultaneously by PS-OCT. Abnormal birefringence was observed in keratoconus cases with advanced thinning and with a rupture of Descemet’s membrane. The graft-host interface of the keratoplasty case showed abnormal birefringence. The appearance of abnormal birefringence in the cornea was likely to be an indication of cross-linking of collagen fibrils. The measurement of rabbit showed abnormal birefringence in the scarring eyes. Wide regions of strong birefringence were observed in the eyes of trabeculectomy patients who had high intraocular pressure. Visualization of scarring in bleb by PS-OCT may be useful for the planning of secondary surgery. PS-OCT showed promising for the study and diagnosis diseases related to abnormal fibrous tissues of the cornea and anterior eye segment.

© 2011 OSA

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Ophthalmology Applications

History
Original Manuscript: June 10, 2011
Revised Manuscript: July 11, 2011
Manuscript Accepted: July 26, 2011
Published: July 27, 2011

Citation
Yiheng Lim, Masahiro Yamanari, Shinichi Fukuda, Yuichi Kaji, Takahiro Kiuchi, Masahiro Miura, Tetsuro Oshika, and Yoshiaki Yasuno, "Birefringence measurement of cornea and anterior segment by office-based polarization-sensitive optical coherence tomography," Biomed. Opt. Express 2, 2392-2402 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-8-2392


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