OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 9 — Sep. 1, 2011
  • pp: 2551–2561

Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization

Yi Yang, Xiang Li, Tianheng Wang, Patrick D. Kumavor, Andres Aguirre, Kirk K. Shung, Qifa Zhou, Melinda Sanders, Molly Brewer, and Quing Zhu  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 9, pp. 2551-2561 (2011)
http://dx.doi.org/10.1364/BOE.2.002551


View Full Text Article

Enhanced HTML    Acrobat PDF (3973 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Ovarian cancer has the lowest survival rate of the gynecologic cancers because it is predominantly diagnosed in Stages III or IV due to the lack of reliable symptoms, as well as the lack of efficacious screening techniques. Detection before the malignancy spreads or at the early stage would greatly improve the survival and benefit patient health. In this report, we present an integrated optical coherence tomography (OCT), ultrasound (US) and photoacoustic imaging (PAI) prototype endoscopy system for ovarian tissue characterization. The overall diameter of the prototype endoscope is 5 mm which is suitable for insertion through a standard 5-12.5mm endoscopic laparoscopic port during minimally invasive surgery. It consists of a ball-lensed OCT sample arm probe, a multimode fiber having the output end polished at 45 degree angle so as to deliver the light perpendicularly for PAI, and a high frequency ultrasound transducer with 35MHz center frequency. System characterizations of OCT, US and PAI are presented. In addition, results obtained from ex vivo porcine and human ovarian tissues are presented. The optical absorption contrast provided by PAI, the high resolution subsurface morphology provided by OCT, and the deeper tissue structure imaged by US demonstrate the synergy of the combined endoscopy and the superior performance of this hybrid device over each modality alone in ovarian tissue characterization.

© 2011 OSA

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Multimodal Imaging

History
Original Manuscript: July 7, 2011
Revised Manuscript: July 31, 2011
Manuscript Accepted: August 4, 2011
Published: August 5, 2011

Citation
Yi Yang, Xiang Li, Tianheng Wang, Patrick D. Kumavor, Andres Aguirre, Kirk K. Shung, Qifa Zhou, Melinda Sanders, Molly Brewer, and Quing Zhu, "Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization," Biomed. Opt. Express 2, 2551-2561 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-9-2551


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. T. R. Rebbeck, H. T. Lynch, S. L. Neuhausen, S. A. Narod, L. Van’t Veer, J. E. Garber, G. Evans, C. Isaacs, M. B. Daly, E. Matloff, O. I. Olopade, B. L. Weber, and Prevention and Observation of Surgical End Points Study Group, “Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations,” N. Engl. J. Med. 346(21), 1616–1622 (2002). [CrossRef] [PubMed]
  2. N. D. Kauff, J. M. Satagopan, M. E. Robson, L. Scheuer, M. Hensley, C. A. Hudis, N. A. Ellis, J. Boyd, P. I. Borgen, R. R. Barakat, L. Norton, M. Castiel, K. Nafa, and K. Offit, “Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation,” N. Engl. J. Med. 346(21), 1609–1615 (2002). [CrossRef] [PubMed]
  3. W. A. Rocca, B. R. Grossardt, M. de Andrade, G. D. Malkasian, and L. J. Melton, “Survival patterns after oophorectomy in premenopausal women: a population-based cohort study,” Lancet Oncol. 7(10), 821–828 (2006). [CrossRef] [PubMed]
  4. J. S. Berek, E. Chalas, M. Edelson, D. H. Moore, W. M. Burke, W. A. Cliby, A. Berchuck, and Society of Gynecologic Oncologists Clinical Practice Committee, “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer,” Obstet. Gynecol. 116(3), 733–743 (2010). [CrossRef] [PubMed]
  5. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991). [CrossRef] [PubMed]
  6. V. J. Srinivasan, Y. Chen, J. S. Duker, and J. G. Fujimoto, “In vivo functional imaging of intrinsic scattering changes in the human retina with high-speed ultrahigh resolution OCT,” Opt. Express 17(5), 3861–3877 (2009). [CrossRef] [PubMed]
  7. R. K. Wang, L. An, P. Francis, and D. J. Wilson, “Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography,” Opt. Lett. 35(9), 1467–1469 (2010). [CrossRef] [PubMed]
  8. L. Yu and Z. Chen, “Doppler variance imaging for three-dimensional retina and choroid angiography,” J. Biomed. Opt. 15(1), 016029 (2010). [CrossRef] [PubMed]
  9. G. J. Tearney, H. Yabushita, S. L. Houser, H. T. Aretz, I. K. Jang, K. H. Schlendorf, C. R. Kauffman, M. Shishkov, E. F. Halpern, and B. E. Bouma, “Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography,” Circulation 107(1), 113–119 (2003). [CrossRef] [PubMed]
  10. P. Barlis, P. W. Serruys, N. Gonzalo, W. J. van der Giessen, P. J. de Jaegere, and E. Regar, “Assessment of culprit and remote coronary narrowings using optical coherence tomography with long-term outcomes,” Am. J. Cardiol. 102(4), 391–395 (2008). [CrossRef] [PubMed]
  11. P. A. Testoni and B. Mangiavillano, “Optical coherence tomography in detection of dysplasia and cancer of the gastrointestinal tract and bilio-pancreatic ductal system,” World J. Gastroenterol. 14(42), 6444–6452 (2008). [CrossRef] [PubMed]
  12. M. J. Cobb, J. H. Hwang, M. P. Upton, Y. C. Chen, B. K. Oelschlager, D. E. Wood, M. B. Kimmey, and X. Li, “Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study,” Gastrointest. Endosc. 71(2), 223–230 (2010). [CrossRef] [PubMed]
  13. J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006). [CrossRef] [PubMed]
  14. E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006). [CrossRef] [PubMed]
  15. L. P. Hariri, G. T. Bonnema, K. Schmidt, A. M. Winkler, V. Korde, K. D. Hatch, J. R. Davis, M. A. Brewer, and J. K. Barton, “Laparoscopic optical coherence tomography imaging of human ovarian cancer,” Gynecol. Oncol. 114(2), 188–194 (2009). [CrossRef] [PubMed]
  16. C. L. Evans, I. Rizvi, T. Hasan, and J. F. de Boer, “In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging,” Opt. Express 17(11), 8892–8906 (2009). [CrossRef] [PubMed]
  17. Y. Yang, N. C. Biswal, T. Wang, P. D. Kumavor, M. Karimeddini, J. Vento, M. Sanders, M. Brewer, and Q. Zhu, “Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization,” Biomed. Opt. Express 2(7), 1918–1930 (2011). [CrossRef] [PubMed]
  18. M. A. Brewer, U. Utzinger, J. K. Barton, J. B. Hoying, N. D. Kirkpatrick, W. R. Brands, J. R. Davis, K. Hunt, S. J. Stevens, and A. F. Gmitro, “Imaging of the ovary,” Technol. Cancer Res. Treat. 3(6), 617–627 (2004). [PubMed]
  19. V. G. Andreev, A. A. Karabutov, S. V. Solomatin, E. V. Savateeva, V. Aleinikov, Y. V. Zhulina, R. D. Fleming, and A. Oraevsky, “Optoacoustic tomography of breast cancer with arc-array transducer,” Proc. SPIE 3916, 36–47 (2000). [CrossRef]
  20. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003). [CrossRef] [PubMed]
  21. N. Weidner, J. P. Semple, W. R. Welch, and J. Folkman, “Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma,” N. Engl. J. Med. 324(1), 1–8 (1991). [CrossRef] [PubMed]
  22. P. Vaupel, F. Kallinowski, and P. Okunieff, “Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review,” Cancer Res. 49(23), 6449–6465 (1989). [PubMed]
  23. A. Aguirre, Y. Ardeshirpour, M. M. Sanders, M. Brewer, and Q. Zhu, “Potential role of coregistered photoacoustic and ultrasound imaging in ovarian cancer detection and characterization,” Transl Oncol 4(1), 29–37 (2011). [PubMed]
  24. J.-M. Yang, K. Maslov, H.-C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett. 34(10), 1591–1593 (2009). [CrossRef] [PubMed]
  25. X. Li, J. Yin, C. Hu, Q. Zhou, K. K. Shung, and Z. P. Chen, “High-resolution coregistered intravascular imaging with integrated ultrasound and optical coherence tomography probe,” Appl. Phys. Lett. 97(13), 133702 (2010). [CrossRef] [PubMed]
  26. J. Yin, H.-C. Yang, X. Li, J. Zhang, Q. Zhou, C. Hu, K. K. Shung, and Z. P. Chen, “Integrated intravascular optical coherence tomography ultrasound imaging system,” J. Biomed. Opt. 15(1), 010512 (2010). [CrossRef] [PubMed]
  27. B. Wang, J. L. Su, J. Amirian, S. H. Litovsky, R. Smalling, and S. Emelianov, “Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging,” Opt. Express 18(5), 4889–4897 (2010). [CrossRef] [PubMed]
  28. L. Li, K. Maslov, G. Ku, and L. V. Wang, “Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies,” Opt. Express 17(19), 16450–16455 (2009). [CrossRef] [PubMed]
  29. S. Jiao, M. Jiang, J. Hu, A. Fawzi, Q. Zhou, K. K. Shung, C. A. Puliafito, and H. F. Zhang, “Photoacoustic ophthalmoscopy for in vivo retinal imaging,” Opt. Express 18(4), 3967–3972 (2010). [CrossRef] [PubMed]
  30. J. Gamelin, Y. Yang, N. Biswal, Y. Chen, S. Yan, X. Zhang, M. Karemeddini, M. Brewer, and Q. Zhu, “A prototype hybrid intraoperative probe for ovarian cancer detection,” Opt. Express 17(9), 7245–7258 (2009). [CrossRef] [PubMed]
  31. C.-K. Liao, M.-L. Li, and P.-C. Li, “Optoacoustic imaging with synthetic aperture focusing and coherence weighting,” Opt. Lett. 29(21), 2506–2508 (2004). [CrossRef] [PubMed]
  32. Y. Yang, N. C. Biswal, T. Wang, P. D. Kumavor, M. Karimeddini, J. Vento, M. Sanders, M. Brewer, and Q. Zhu, “Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization,” Biomed. Opt. Express 2(7), 1918–1930 (2011). [CrossRef] [PubMed]
  33. F. S. Foster, C. J. Pavlin, K. A. Harasiewicz, D. A. Christopher, and D. H. Turnbull, “Advances in ultrasound biomicroscopy,” Ultrasound Med. Biol. 26(1), 1–27 (2000). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited