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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 9 — Sep. 1, 2011
  • pp: 2562–2568

Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat

Justin Wanek, Pang-yu Teng, John Albers, Norman P. Blair, and Mahnaz Shahidi  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 9, pp. 2562-2568 (2011)
http://dx.doi.org/10.1364/BOE.2.002562


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Abstract

The metabolic function of inner retinal cells relies on the availability of nutrients and oxygen that are supplied by the retinal circulation. Assessment of retinal tissue vitality and function requires knowledge of both the rate of oxygen delivery and consumption. The purpose of the current study is to report a novel technique for assessment of the inner retinal metabolic rate of oxygen (MO2) by combined measurements of retinal blood flow and vascular oxygen tension (PO2) in rat. The application of this technology has the potential to broaden knowledge of retinal oxygen dynamics and advance understanding of disease pathophysiology.

© 2011 OSA

OCIS Codes
(100.2960) Image processing : Image analysis
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Functional Imaging

History
Original Manuscript: June 24, 2011
Revised Manuscript: July 29, 2011
Manuscript Accepted: July 29, 2011
Published: August 9, 2011

Citation
Justin Wanek, Pang-yu Teng, John Albers, Norman P. Blair, and Mahnaz Shahidi, "Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat," Biomed. Opt. Express 2, 2562-2568 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-9-2562


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