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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 1 — Jan. 1, 2012
  • pp: 16–25

Non-contact photoacoustic tomography and ultrasonography for tissue imaging

Guy Rousseau, Alain Blouin, and Jean-Pierre Monchalin  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 1, pp. 16-25 (2012)

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The detection of ultrasound in photoacoustic tomography (PAT) and ultrasonography (US) usually relies on ultrasonic transducers in contact with the biological tissue. This is a major drawback for important potential applications such as surgery and small animal imaging. Here we report the use of remote optical detection, as used in industrial laser-ultrasonics, to detect ultrasound in biological tissues. This strategy enables non-contact implementation of PAT and US without exceeding laser exposure safety limits. The method uses suitably shaped laser pulses and a confocal Fabry-Perot interferometer in differential configuration to reach quantum-limited sensitivity. Endogenous and exogenous inclusions exhibiting optical and acoustic contrasts were detected ex vivo in chicken breast and calf brain specimens. Inclusions down to 0.5 mm in size were detected at depths well exceeding 1 cm. The method could significantly expand the scope of applications of PAT and US in biomedical imaging.

© 2011 OSA

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(120.0280) Instrumentation, measurement, and metrology : Remote sensing and sensors
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(280.3375) Remote sensing and sensors : Laser induced ultrasonics

ToC Category:
Photoacoustic Imaging and Spectroscopy

Original Manuscript: July 20, 2011
Revised Manuscript: October 14, 2011
Manuscript Accepted: November 22, 2011
Published: December 2, 2011

Virtual Issues
Advances in Optics for Biotechnology, Medicine, and Surgery (2011) Biomedical Optics Express

Guy Rousseau, Alain Blouin, and Jean-Pierre Monchalin, "Non-contact photoacoustic tomography and ultrasonography for tissue imaging," Biomed. Opt. Express 3, 16-25 (2012)

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