Non-contact photoacoustic tomography and ultrasonography for tissue imaging

doi:10.1364/BOE.3.000016

Non-contact photoacoustic tomography and ultrasonography for tissue imaging

Guy Rousseau, Alain Blouin, and Jean-Pierre Monchalin »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 1, pp. 16-25 (2012)
http://dx.doi.org/10.1364/BOE.3.000016

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Abstract

The detection of ultrasound in photoacoustic tomography (PAT) and ultrasonography (US) usually relies on ultrasonic transducers in contact with the biological tissue. This is a major drawback for important potential applications such as surgery and small animal imaging. Here we report the use of remote optical detection, as used in industrial laser-ultrasonics, to detect ultrasound in biological tissues. This strategy enables non-contact implementation of PAT and US without exceeding laser exposure safety limits. The method uses suitably shaped laser pulses and a confocal Fabry-Perot interferometer in differential configuration to reach quantum-limited sensitivity. Endogenous and exogenous inclusions exhibiting optical and acoustic contrasts were detected ex vivo in chicken breast and calf brain specimens. Inclusions down to 0.5 mm in size were detected at depths well exceeding 1 cm. The method could significantly expand the scope of applications of PAT and US in biomedical imaging.

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(110.7170) Imaging systems : Ultrasound
(120.0280) Instrumentation, measurement, and metrology : Remote sensing and sensors
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(280.3375) Remote sensing and sensors : Laser induced ultrasonics

ToC Category:
Photoacoustic Imaging and Spectroscopy

History
Original Manuscript: July 20, 2011
Revised Manuscript: October 14, 2011
Manuscript Accepted: November 22, 2011
Published: December 2, 2011

Virtual Issues
Advances in Optics for Biotechnology, Medicine, and Surgery (2011) Biomedical Optics Express

Citation
Guy Rousseau, Alain Blouin, and Jean-Pierre Monchalin, "Non-contact photoacoustic tomography and ultrasonography for tissue imaging," Biomed. Opt. Express 3, 16-25 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-1-16

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References

L. V. Wang and H. Wu, Biomedical Optics: Principles and Imaging (Wiley, Hoboken, NJ, 2007).
P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011). [CrossRef]
L. V. Wang, ed., Photoacoustic Imaging and Spectroscopy (CRC Press, Boca Raton, FL, 2009).
V. Ntziachristos, J. S. Yoo, and G. M. van Dam, “Current concepts and future perspectives on surgical optical imaging in cancer,” J. Biomed. Opt.15(6), 066024 (2010). [CrossRef] [PubMed]
S. Jiao, M. Jiang, J. Hu, A. Fawzi, Q. Zhou, K. K. Shung, C. A. Puliafito, and H. F. Zhang, “Photoacoustic ophthalmoscopy for in vivo retinal imaging,” Opt. Express18(4), 3967–3972 (2010). [CrossRef] [PubMed]
X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003). [CrossRef] [PubMed]
E. Z. Zhang, B. Povazay, J. Laufer, A. Alex, B. Hofer, B. Pedley, C. Glittenberg, B. Treeby, B. Cox, P. Beard, and W. Drexler, “Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging,” Biomed. Opt. Express2(8), 2202–2215 (2011). [CrossRef] [PubMed]
R. G. M. Kolkman, E. Blomme, T. Cool, M. Bilcke, T. G. van Leeuwen, W. Steenbergen, K. A. Grimbergen, and G. J. den Heeten, “Feasibility of noncontact piezoelectric detection of photoacoustic signals in tissue-mimicking phantoms,” J. Biomed. Opt.15(5), 055011 (2010). [CrossRef] [PubMed]
Z. Xie, S. L. Chen, T. Ling, L. J. Guo, P. L. Carson, and X. Wang, “Pure optical photoacoustic microscopy,” Opt. Express19(10), 9027–9034 (2011). [CrossRef] [PubMed]
R. Nuster, H. Gruen, B. Reitinger, P. Burgholzer, S. Gratt, K. Passler, and G. Paltauf, “Downstream Fabry-Perot interferometer for acoustic wave monitoring in photoacoustic tomography,” Opt. Lett.36(6), 981–983 (2011). [CrossRef] [PubMed]
B. P. Payne, V. Venugopalan, B. B. Mikić, and N. S. Nishioka, “Optoacoustic tomography using time-resolved interferometric detection of surface displacement,” J. Biomed. Opt.8(2), 273–280 (2003). [CrossRef] [PubMed]
C. B. Scruby and L. E. Drain, Laser-Ultrasonics: Techniques and Applications (Adam Hilger, Bristol, UK, 1990).
J.-P. Monchalin, “Optical detection of ultrasound at a distance using a confocal Fabry-Perot interferometer,” Appl. Phys. Lett.47(1), 14–16 (1985). [CrossRef]
J.-P. Monchalin, “Optical detection of ultrasound,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control33(5), 485–499 (1986). [CrossRef] [PubMed]
R. K. Ing and J.-P. Monchalin, “Broadband optical detection of ultrasound by two-wave mixing in a photorefractive crystal,” Appl. Phys. Lett.59(25), 3233–3235 (1991). [CrossRef]
A. Blouin and J.-P. Monchalin, “Detection of ultrasonic motion of a scattering surface by two-wave mixing in a photorefractive GaAs crystal,” Appl. Phys. Lett.65(8), 932–934 (1994). [CrossRef]
American National Standard for the Safe Use of Lasers ANSI Z136, 1–2007 (Laser Institute of America, Orlando, Florida, 2007).
T. Berer, A. Hochreiner, S. Zamiri, and P. Burgholzer, “Remote photoacoustic imaging on solid material using a two-wave mixing interferometer,” Opt. Lett.35(24), 4151–4153 (2010). [CrossRef] [PubMed]
A. Blouin, C. Padioleau, C. Néron, D. Lévesque, and J.-P. Monchalin, “Differential confocal Fabry-Perot for the optical detection of ultrasound,” in Review of Progress in Quantitative Nondestructive Evaluation, AIP Conference Proceedings, Volume 894 (AIP, NY, 2007), pp. 193–200.
J. Davies, F. Simonetti, M. Lowe, and P. Cawley, “Review of synthetically focused guided wave imaging techniques with application to defect sizing,” in Quantitative Nondestructive Evaluation, AIP Conference Proceedings, Volume 820 (AIP, NY, 2006), pp. 142–149.
D. Lévesque, A. Blouin, C. Néron, and J. P. Monchalin, “Performance of laser-ultrasonic F-SAFT imaging,” Ultrasonics40(10), 1057–1063 (2002). [CrossRef] [PubMed]
S. Prahl, “Optical absorption of hemoglobin,” http://omlc.ogi.edu/spectra/hemoglobin/index.html .
A. A. Oraevsky, V. G. Andreev, A. A. Karabutov, and R. O. Esenaliev, “Two-dimensional opto-acoustic tomography transducer array and image reconstruction algorithm,” Proc. SPIE3601, 256–267 (1999). [CrossRef]

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[1] L. V. Wang and H. Wu, Biomedical Optics: Principles and Imaging (Wiley, Hoboken, NJ, 2007).

[2] P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011). [CrossRef]

[3] L. V. Wang, ed., Photoacoustic Imaging and Spectroscopy (CRC Press, Boca Raton, FL, 2009).

[4] V. Ntziachristos, J. S. Yoo, and G. M. van Dam, “Current concepts and future perspectives on surgical optical imaging in cancer,” J. Biomed. Opt.15(6), 066024 (2010). [CrossRef] [PubMed]

[5] S. Jiao, M. Jiang, J. Hu, A. Fawzi, Q. Zhou, K. K. Shung, C. A. Puliafito, and H. F. Zhang, “Photoacoustic ophthalmoscopy for in vivo retinal imaging,” Opt. Express18(4), 3967–3972 (2010). [CrossRef] [PubMed]

[6] X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003). [CrossRef] [PubMed]

[7] E. Z. Zhang, B. Povazay, J. Laufer, A. Alex, B. Hofer, B. Pedley, C. Glittenberg, B. Treeby, B. Cox, P. Beard, and W. Drexler, “Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging,” Biomed. Opt. Express2(8), 2202–2215 (2011). [CrossRef] [PubMed]

[8] R. G. M. Kolkman, E. Blomme, T. Cool, M. Bilcke, T. G. van Leeuwen, W. Steenbergen, K. A. Grimbergen, and G. J. den Heeten, “Feasibility of noncontact piezoelectric detection of photoacoustic signals in tissue-mimicking phantoms,” J. Biomed. Opt.15(5), 055011 (2010). [CrossRef] [PubMed]

[9] Z. Xie, S. L. Chen, T. Ling, L. J. Guo, P. L. Carson, and X. Wang, “Pure optical photoacoustic microscopy,” Opt. Express19(10), 9027–9034 (2011). [CrossRef] [PubMed]

[10] R. Nuster, H. Gruen, B. Reitinger, P. Burgholzer, S. Gratt, K. Passler, and G. Paltauf, “Downstream Fabry-Perot interferometer for acoustic wave monitoring in photoacoustic tomography,” Opt. Lett.36(6), 981–983 (2011). [CrossRef] [PubMed]

[11] B. P. Payne, V. Venugopalan, B. B. Mikić, and N. S. Nishioka, “Optoacoustic tomography using time-resolved interferometric detection of surface displacement,” J. Biomed. Opt.8(2), 273–280 (2003). [CrossRef] [PubMed]

[12] C. B. Scruby and L. E. Drain, Laser-Ultrasonics: Techniques and Applications (Adam Hilger, Bristol, UK, 1990).

[13] J.-P. Monchalin, “Optical detection of ultrasound at a distance using a confocal Fabry-Perot interferometer,” Appl. Phys. Lett.47(1), 14–16 (1985). [CrossRef]

[14] J.-P. Monchalin, “Optical detection of ultrasound,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control33(5), 485–499 (1986). [CrossRef] [PubMed]

[15] R. K. Ing and J.-P. Monchalin, “Broadband optical detection of ultrasound by two-wave mixing in a photorefractive crystal,” Appl. Phys. Lett.59(25), 3233–3235 (1991). [CrossRef]

[16] A. Blouin and J.-P. Monchalin, “Detection of ultrasonic motion of a scattering surface by two-wave mixing in a photorefractive GaAs crystal,” Appl. Phys. Lett.65(8), 932–934 (1994). [CrossRef]

[17] American National Standard for the Safe Use of Lasers ANSI Z136, 1–2007 (Laser Institute of America, Orlando, Florida, 2007).

[18] T. Berer, A. Hochreiner, S. Zamiri, and P. Burgholzer, “Remote photoacoustic imaging on solid material using a two-wave mixing interferometer,” Opt. Lett.35(24), 4151–4153 (2010). [CrossRef] [PubMed]

[19] A. Blouin, C. Padioleau, C. Néron, D. Lévesque, and J.-P. Monchalin, “Differential confocal Fabry-Perot for the optical detection of ultrasound,” in Review of Progress in Quantitative Nondestructive Evaluation, AIP Conference Proceedings, Volume 894 (AIP, NY, 2007), pp. 193–200.

[20] J. Davies, F. Simonetti, M. Lowe, and P. Cawley, “Review of synthetically focused guided wave imaging techniques with application to defect sizing,” in Quantitative Nondestructive Evaluation, AIP Conference Proceedings, Volume 820 (AIP, NY, 2006), pp. 142–149.

[21] D. Lévesque, A. Blouin, C. Néron, and J. P. Monchalin, “Performance of laser-ultrasonic F-SAFT imaging,” Ultrasonics40(10), 1057–1063 (2002). [CrossRef] [PubMed]

[22] S. Prahl, “Optical absorption of hemoglobin,” http://omlc.ogi.edu/spectra/hemoglobin/index.html .

[23] A. A. Oraevsky, V. G. Andreev, A. A. Karabutov, and R. O. Esenaliev, “Two-dimensional opto-acoustic tomography transducer array and image reconstruction algorithm,” Proc. SPIE3601, 256–267 (1999). [CrossRef]

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Non-contact photoacoustic tomography and ultrasonography for tissue imaging